New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases

被引：32
作者：
Disatnik, Marie-Helene [1 ]
Hwang, Sunhee [1 ]
Ferreira, Julio C. B. [2 ]
Mochly-Rosen, Daria [1 ,3 ]
机构：
[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, BR-05508000 Sao Paulo, Brazil
[3] Stanford Univ, Sch Med, Dept Chem & Syst Biol, CCSR, Stanford, CA 94305 USA
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 2015年 / 93卷 / 03期
基金：
美国国家卫生研究院; 巴西圣保罗研究基金会;
关键词：
Cardiac disease; Mitochondria; Mitophagy; Autophagy; Fission; Fusion; Mitochondrial dynamics; Heart; ISCHEMIA-REPERFUSION; CELL-DEATH; ISCHEMIA/REPERFUSION INJURY; MOLECULAR-MECHANISMS; MYOCARDIAL-ISCHEMIA; OXIDATIVE STRESS; REACTIVE OXYGEN; PROTEIN-KINASE; FISSION; HEART;
D O I：
10.1007/s00109-015-1256-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The processes that control the number and shape of the mitochondria (mitochondrial dynamics) and the removal of damaged mitochondria (mitophagy) have been the subject of intense research. Recent work indicates that these processes may contribute to the pathology associated with cardiac diseases. This review describes some of the key proteins that regulate these processes and their potential as therapeutic targets for cardiac diseases.
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收藏
页码：279 / 287
页数：9
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