New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases

被引：32
作者：
Disatnik, Marie-Helene [1 ]
Hwang, Sunhee [1 ]
Ferreira, Julio C. B. [2 ]
Mochly-Rosen, Daria [1 ,3 ]
机构：
[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, BR-05508000 Sao Paulo, Brazil
[3] Stanford Univ, Sch Med, Dept Chem & Syst Biol, CCSR, Stanford, CA 94305 USA
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 2015年 / 93卷 / 03期
基金：
巴西圣保罗研究基金会; 美国国家卫生研究院;
关键词：
Cardiac disease; Mitochondria; Mitophagy; Autophagy; Fission; Fusion; Mitochondrial dynamics; Heart; ISCHEMIA-REPERFUSION; CELL-DEATH; ISCHEMIA/REPERFUSION INJURY; MOLECULAR-MECHANISMS; MYOCARDIAL-ISCHEMIA; OXIDATIVE STRESS; REACTIVE OXYGEN; PROTEIN-KINASE; FISSION; HEART;
D O I：
10.1007/s00109-015-1256-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The processes that control the number and shape of the mitochondria (mitochondrial dynamics) and the removal of damaged mitochondria (mitophagy) have been the subject of intense research. Recent work indicates that these processes may contribute to the pathology associated with cardiac diseases. This review describes some of the key proteins that regulate these processes and their potential as therapeutic targets for cardiac diseases.
引用
收藏
页码：279 / 287
页数：9
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共 77 条
  • [1] Mitochondria as a Therapeutic Target in Heart Failure
    Bayeva, Marina
    Gheorghiade, Mihai
    Ardehali, Hossein
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (06) : 599 - 610
  • [2] Enhanced autophagy ameliorates cardiac proteinopathy
    Bhuiyan, Md. Shenuarin
    Pattison, J. Scott
    Osinska, Hanna
    James, Jeanne
    Gulick, James
    McLendon, Patrick M.
    Hill, Joseph A.
    Sadoshima, Junichi
    Robbins, Jeffrey
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (12) : 5284 - 5297
  • [3] PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function
    Billia, Filio
    Hauck, Ludger
    Konecny, Filip
    Rao, Vivek
    Shen, Jie
    Mak, Tak Wah
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (23) : 9572 - 9577
  • [4] Pim-1 Kinase Protects Mitochondrial Integrity in Cardiomyocytes
    Borillo, Gwynngelle A.
    Mason, Matt
    Quijada, Pearl
    Voelkers, Mirko
    Cottage, Christopher
    McGregor, Michael
    Din, Shabana
    Fischer, Kimberlee
    Gude, Natalie
    Avitabile, Daniele
    Barlow, Steven
    Alvarez, Roberto
    Truffa, Silvia
    Whittaker, Ross
    Glassy, Matthew S.
    Gustafsson, Asa B.
    Miyamoto, Shigeki
    Glembotski, Christopher C.
    Gottlieb, Roberta A.
    Brown, Joan Heller
    Sussman, Mark A.
    [J]. CIRCULATION RESEARCH, 2010, 106 (07) : 1265 - U201
  • [5] The role of mitochondria in aging
    Bratic, Ana
    Larsson, Nils-Goran
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (03) : 951 - 957
  • [6] Exercise Training Restores Cardiac Protein Quality Control in Heart Failure
    Campos, Juliane C.
    Queliconi, Bruno B.
    Dourado, Paulo M. M.
    Cunha, Telma F.
    Zambelli, Vanessa O.
    Bechara, Luiz R. G.
    Kowaltowski, Alicia J.
    Brum, Patricia C.
    Mochly-Rosen, Daria
    Ferreira, Julio C. B.
    [J]. PLOS ONE, 2012, 7 (12):
  • [7] OPA1 Mutation and Late-Onset Cardiomyopathy: Mitochondrial Dysfunction and mtDNA Instability
    Chen, Le
    Liu, Tingting
    Alice Tran
    Lu, Xiyuan
    Tomilov, Alexey A.
    Davies, Vanessa
    Cortopassi, Gino
    Chiamvimonvat, Nipavan
    Bers, Donald M.
    Votruba, Marcela
    Knowlton, Anne A.
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2012, 1 (05): : e003012
  • [8] Mitochondrial OPA1, apoptosis, and heart failure
    Chen, Le
    Gong, Qizhi
    Stice, James P.
    Knowlton, Anne A.
    [J]. CARDIOVASCULAR RESEARCH, 2009, 84 (01) : 91 - 99
  • [9] PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
    Chen, Yun
    Dorn, Gerald W., II
    [J]. SCIENCE, 2013, 340 (6131) : 471 - 475
  • [10] Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis
    Chen, Yun
    Liu, Yingqiu
    Dorn, Gerald W., III
    [J]. CIRCULATION RESEARCH, 2011, 109 (12) : 1327 - U36
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