Harnessing transposons for cancer gene discovery

被引：117

作者：

Copeland, Neal G. ^{[1
]}

Jenkins, Nancy A. ^{[1
]}

机构：

[1] Agcy Sci Technol & Res, Genom & Genet Div, Inst Mol & Cell Biol, Singapore 138673, Singapore

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 10期

关键词：

SLEEPING-BEAUTY TRANSPOSITION; GROWTH-FACTOR-RECEPTOR; HEPATITIS-B-VIRUS; CHROMOSOMAL TRANSPOSITION; HEPATOCELLULAR-CARCINOMA; CYTOSINE METHYLATION; SOMATIC MUTAGENESIS; BACULOVIRUS GENOME; ESTROGEN-RECEPTOR; INSERTION SITES;

D O I：

10.1038/nrc2916

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, it has become possible to mobilize the Tc1/mariner transposon, Sleeping Beauty (SB), in mouse somatic cells at frequencies high enough to induce cancer. Tumours result from SB insertional mutagenesis of cancer genes, thus facilitating the identification of the genes and signalling pathways that drive tumour formation. A conditional SB transposition system has also been developed that makes it possible to limit where SB mutagenesis occurs, providing a means to selectively model many types of human cancer. SB mutagenesis has already identified a large collection of known cancer genes in addition to a plethora of new candidate cancer genes and potential drug targets.

引用

页码：696 / 706

页数：11

共 102 条

[41] TRANSPLANTABLE MYELOPROLIFERATIVE DISEASE INDUCED IN MICE BY AN INTERLEUKIN-6 RETROVIRUS [J].

HAWLEY, RG ;

FONG, AZC ;

BURNS, BF ;

HAWLEY, TS .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (04) :1149-1163

[42] Characterization of Sleeping Beauty transposition and its application to genetic screening in mice [J].

Horie, K ;

Yusa, K ;

Yae, K ;

Odajima, J ;

Fischer, SEJ ;

Keng, VW ;

Hayakawa, T ;

Mizuno, S ;

Kondoh, G ;

Ijiri, T ;

Matsuda, Y ;

Plasterk, RHA ;

Takeda, J .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (24) :9189-9207

[43] Efficient chromosomal transposition of a Tc1/mariner-like transposon Sleeping Beauty in mice [J].

Horie, K ;

Kuroiwa, A ;

Ikawa, M ;

Okabe, M ;

Kondoh, G ;

Matsuda, Y ;

Takeda, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (16) :9191-9196

[44] Sleeping Beauty transposase has an affinity for heterochromatin conformation [J].

Ikeda, Ryuji ;

Kokubu, Chikara ;

Yusa, Kosuke ;

Keng, Vincent W. ;

Horie, Kyoji ;

Takeda, Junji .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (05) :1665-1676

[45] Comparing antibody and small-molecule therapies for cancer [J].

Imai, Kohzoh ;

Takaoka, Akinori .

NATURE REVIEWS CANCER, 2006, 6 (09) :714-727

[46] Molecular reconstruction of Sleeping beauty, a Tc1-like transposon from fish, and its transposition in human cells [J].

Ivics, Z ;

Hackett, PB ;

Plasterk, RH ;

Izsvak, Z .

CELL, 1997, 91 (04) :501-510

[47] Identification of functional domains and evolution of Tc1-like transposable elements [J].

Ivics, Z ;

Izsvak, Z ;

Minter, A ;

Hackett, PB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (10) :5008-5013

[48] Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates [J].

Izsvák, Z ;

Ivics, Z ;

Plasterk, RH .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 302 (01) :93-102

[49] Healing the wounds inflicted by Sleeping Beauty transposition by double-strand break repair in mammalian somatic cells [J].

Izsvák, Z ;

Stüwe, EE ;

Fiedler, D ;

Katzer, A ;

Jeggo, PA ;

Ivics, Z .

MOLECULAR CELL, 2004, 13 (02) :279-290

[50] Repetitive elements and their genetic applications in zebrafish [J].

Izsvák, Z ;

Ivics, Z ;

Hackett, FB .

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1997, 75 (05) :507-523

← 1 2 3 4 5 6 7 8 9 10 →