Mechanisms and Pharmaceutical Action of Lipid Nanoformulation of Natural Bioactive Compounds as Efficient Delivery Systems in the Therapy of Osteoarthritis

被引:9
作者
Craciunescu, Oana [1 ]
Icriverzi, Madalina [2 ]
Florian, Paula Ecaterina [2 ]
Roseanu, Anca [2 ]
Trif, Mihaela [2 ]
机构
[1] Natl Inst R&D Biol Sci, 296 Splaiul Independentei, Bucharest 060031, Romania
[2] Romanian Acad, Inst Biochem, 296 Splaiul Independentei, Bucharest 060031, Romania
关键词
liposomes; osteoarthritis; intra-articular; polysaccharides; polyphenols; anti-inflammatory activity; INTRAARTICULAR DRUG-DELIVERY; NF-KAPPA-B; CARTILAGE MATRIX DEGRADATION; CHONDROITIN SULFATE; KNEE OSTEOARTHRITIS; HYALURONIC-ACID; IN-VITRO; ARTICULAR-CARTILAGE; IL-1-BETA-INDUCED EXPRESSION; INFLAMMATORY MEDIATORS;
D O I
10.3390/pharmaceutics13081108
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Osteoarthritis (OA) is a degenerative joint disease. An objective of the nanomedicine and drug delivery systems field is to design suitable pharmaceutical nanocarriers with controllable properties for drug delivery and site-specific targeting, in order to achieve greater efficacy and minimal toxicity, compared to the conventional drugs. The aim of this review is to present recent data on natural bioactive compounds with anti-inflammatory properties and efficacy in the treatment of OA, their formulation in lipid nanostructured carriers, mainly liposomes, as controlled release systems and the possibility to be intra-articularly (IA) administered. The literature regarding glycosaminoglycans, proteins, polyphenols and their ability to modify the cell response and mechanisms of action in different models of inflammation are reviewed. The advantages and limits of using lipid nanoformulations as drug delivery systems in OA treatment and the suitable route of administration are also discussed. Liposomes containing glycosaminoglycans presented good biocompatibility, lack of immune system activation, targeted delivery of bioactive compounds to the site of action, protection and efficiency of the encapsulated material, and prolonged duration of action, being highly recommended as controlled delivery systems in OA therapy through IA administration. Lipid nanoformulations of polyphenols were tested both in vivo and in vitro models that mimic OA conditions after IA or other routes of administration, recommending their clinical application.
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页数:24
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