Pyrazolopyrimidines as anticancer agents: A review on structural and target-based approaches

被引：50

作者：

Asati, Vivek ^{[1
]}

Anant, Arjun ^{[1
]}

Patel, Preeti ^{[1
]}

Kaur, Kamalpreet ^{[1
]}

Gupta, G. D. ^{[2
]}

机构：

[1] ISF Coll Pharm, Dept Pharmaceut Chem, Moga, Punjab, India

[2] ISF Coll Pharm, Dept Pharmaceut, Moga, Punjab, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 225卷

关键词：

Pyrazolo-pyrimidines; Kinase; Targets; SAR; Anticancer; BIOLOGICAL EVALUATION; SELECTIVE INHIBITOR; ANTITUMOR-ACTIVITY; MOLECULAR DOCKING; PHENYL AMIDES; POTENT; DERIVATIVES; CHEMISTRY; ANALOGS; DESIGN;

D O I：

10.1016/j.ejmech.2021.113781

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pyrazolopyrimidine scaffold is one of the privileged heterocycles in drug discovery. This scaffold produced numerous biological activities in which anticancer is important one. Previous studies showed its importance in interactions with various receptors such as growth factor receptor, TGFBR2 gene, CDK2/cyclin E and Abl kinase, adenosine receptor, calcium-dependent Protein Kinase, Pim-1 kinase, Potent Janus kinase 2, BTK kinase, P21-activated kinase 1, extracellular signal-regulated kinase 2, histone lysine demethylase and Human Kinesin-5. However, there is a need of numerous studies for the discovery of target based potential compounds. The structure activity relationship studies may help to explore the generation of potential compounds in short time period. Therefore, in the present review we tried to explore the structural aspects of Pyrazolopyrimidine with their structure activity relationship against various targets for the development of potential compounds. The current review is the compilation of significant advances made on Pyrazolopyrimidines reported between 2015 and 2020. (C) 2021 Published by Elsevier Masson SAS.

引用

页数：31

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