Evidence for Participation of Aluminum in Neurofibrillary Tangle Formation and Growth in Alzheimer's Disease

被引：64
作者：
Walton, J. R. [1 ]
机构：
[1] Univ New S Wales, St George Hosp, Sch Clin, Res & Educ Ctr,Fac Med, Sydney, NSW 2217, Australia
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 22卷 / 01期
基金：
英国医学研究理事会;
关键词：
Aluminum; Alzheimer's disease; hyperphosphorylated tau; neurofibrillary tangles; PAIRED HELICAL FILAMENTS; ABNORMALLY PHOSPHORYLATED-TAU; PROTEIN PHOSPHATASE 2A; INDUCED APOPTOSIS; HYPERPHOSPHORYLATED-TAU; CEREBRAL-CORTEX; PHF-TAU; BRAIN; ACCUMULATION; DEGENERATION;
D O I：
10.3233/JAD-2010-100486
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study examines hippocampal CA1 cells from brains of aged humans, with and without Alzheimer's disease, for hyperphosphorylated tau and aluminum during early neurofibrillary tangle (NFT) formation and growth. A very small proportion of hippocampal pyramidal cells contain cytoplasmic pools within their soma that either appear homogeneous or contain short filaments (i.e., early NFTs). The cytoplasmic pools are aggregates of an aluminum/hyperphosphorylated tau complex similar to that found in mature NFTs. The photographic evidence presented combines with existing evidence to support a role for aluminum in the formation and growth of NFTs in neurons of humans with Alzheimer's disease.
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页码：65 / 72
页数：8
相关论文
共 70 条
  • [1] Concerning unsual medical cases in old age
    Alzheimer, A
    [J]. ZEITSCHRIFT FUR DIE GESAMTE NEUROLOGIE UND PSYCHIATRIE, 1911, 4 : 356 - 385
  • [2] Alzheimer A., 1907, Zentrabl, Nervenheilk., V30, P177
  • [3] ACCUMULATION OF ABNORMALLY PHOSPHORYLATED-TAU PRECEDES THE FORMATION OF NEUROFIBRILLARY TANGLES IN ALZHEIMERS-DISEASE
    BANCHER, C
    BRUNNER, C
    LASSMANN, H
    BUDKA, H
    JELLINGER, K
    WICHE, G
    SEITELBERGER, F
    GRUNDKEIQBAL, I
    IQBAL, K
    WISNIEWSKI, HM
    [J]. BRAIN RESEARCH, 1989, 477 (1-2) : 90 - 99
  • [4] ABNORMAL PHOSPHORYLATION OF TAU-PRECEDES UBIQUITINATION IN NEUROFIBRILLARY PATHOLOGY OF ALZHEIMER-DISEASE
    BANCHER, C
    GRUNDKEIQBAL, I
    IQBAL, K
    FRIED, VA
    SMITH, HT
    WISNIEWSKI, HM
    [J]. BRAIN RESEARCH, 1991, 539 (01) : 11 - 18
  • [5] ALUMINUM, CHEMICAL PHYSIOLOGY, AND ALZHEIMERS-DISEASE
    BIRCHALL, JD
    CHAPPELL, JS
    [J]. LANCET, 1988, 2 (8618) : 1008 - 1010
  • [6] The neurotoxicity of environmental aluminum is still an issue
    Bondy, Stephen C.
    [J]. NEUROTOXICOLOGY, 2010, 31 (05) : 575 - 581
  • [7] Caspase activation precedes and leads to tangles
    de Calignon, Alix
    Fox, Leora M.
    Pitstick, Rose
    Carlson, George A.
    Bacskai, Brian J.
    Spires-Jones, Tara L.
    Hyman, Bradley T.
    [J]. NATURE, 2010, 464 (7292) : 1201 - U123
  • [8] Ultrastructural study of rat hippocampus after chronic administration of aluminum L-glutamate: an acceleration of the aging process
    Deloncle, R
    Huguet, F
    Fernandez, B
    Quellard, N
    Babin, P
    Guillard, O
    [J]. EXPERIMENTAL GERONTOLOGY, 2001, 36 (02) : 231 - 244
  • [9] Edwardson J A, 1992, Ciba Found Symp, V169, P165
  • [10] The pro-oxidant activity of aluminum
    Exley, C
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2004, 36 (03) : 380 - 387
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