Spontaneous Protein Crowding in Liposomes: A New Vista for the Origin of Cellular Metabolism

被引：95

作者：

Luisi, Pier Luigi ^{[1
]}

Allegretti, Matteo ^{[1
]}

de Souza, Tereza Pereira ^{[2
]}

Steiniger, Frank ^{[3
]}

Fahr, Alfred ^{[2
]}

Stano, Pasquale ^{[1
]}

机构：

[1] Univ RomaTre, Dipartimento Biol, I-00146 Rome, Italy

[2] Univ Jena, Inst Pharm, D-07743 Jena, Germany

[3] Univ Jena, Elektronenmikroskop Zentrum, D-07743 Jena, Germany

来源：

CHEMBIOCHEM | 2010年 / 11卷 / 14期

关键词：

entrapment; liposomes; origins of life; proteins; self-organization; CRYOTRANSMISSION ELECTRON-MICROSCOPY; ENCAPSULATION EFFICIENCY; LIPID VESICLES; CELLS;

D O I：

10.1002/cbic.201000381

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Figure Presented) Ferritin encapsulation inside lipid vesicles reveals the spontaneous formation of protein-rich vesicles. The solute distribution inside the vesicles follows a power law. The important conclusion for origins-of-life scenarios is that the dynamics of membrane closure allow the accumulation of solutes inside primitive cells, thus providing an explanation for the origins of early functional cells. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1989 / 1992

页数：4

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