Ipomoeassins A-E, cytotoxic macrocyclic glycoresins from the leaves of Ipomoea squamosa from the Suriname rainforest

被引：69
作者：
Cao, SG
Guza, RC
Wisse, JH
Miller, JS
Evans, R
Kingston, DGI
机构：
[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA
[2] Bedrijf Geneesmiddelen Voorziening Suriname, Geyersvlijt, Suriname
[3] Missouri Bot Garden, St Louis, MO 63166 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 04期
关键词：
D O I：
10.1021/np049629w
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The new glycoresins, ipomoeassins A-E (1-5), have been isolated from the leaves of Ipomoea squamosa. The structures were elucidated by spectroscopic analyses and chemical transformations. The absolute configurations of C-5 (ipomoeassins 3-5) and C-11 (ipomoeassins 1 and 2) were determined by their derivatives with (R)- and (S)-MPA. All the isolates were active in the A2780 human ovarian cancer cell line assay, and 4 showed the highest activity with an IC50 value of 35 nM.
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页码：487 / 492
页数：6
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