IL-1α, IL-6 and IL-8 serum values in patients with chronic suppurative otitis media

被引：4

作者：

Serban, Roxana ^{[1
,2
]}

Filip, Cristiana ^{[1
]}

Radulescu, Luminita ^{[2
,3
]}

Badescu, Minerva ^{[4
]}

Badescu, Magda ^{[5
]}

Diaconescu, Bogdan ^{[6
]}

Cobzeanu, Mihail ^{[3
]}

Cobzeanu, Bogdan ^{[2
,3
]}

机构：

[1] Grigore T PopaUniv Med & Pharm, Dept Biochem, 16 Univ St, Iasi 700115, Romania

[2] Clin Rehabil Hosp, Iasi 700656, Romania

[3] Grigore T Popa Univ Med & Pharm, Dept Otorhinolaryngol, Iasi 700115, Romania

[4] Grigore T Popa Univ Med & Pharm, Dept Internal Med, 16 Univ St, Iasi 700115, Romania

[5] Grigore T Popa Univ Med & Pharm, Dept Physiopathol, Iasi 700115, Romania

[6] Grigore T Popa Univ Med & Pharm, Dept Occupat Med, Iasi 700115, Romania

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2021年 / 22卷 / 05期

关键词：

interleukins; cholesteatoma; cholesteatoma recidivism; chronic suppurative otitis media; CYTOKINES; INTERLEUKIN-6; ACTIVATION; EXPRESSION; ALPHA;

D O I：

10.3892/etm.2021.10660

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Inflammatory mediators play an important role in the pathogenesis of otitis media by initiating and maintaining an inflammatory response to infection. The presence of inflammatory mediators may be one of the reasons, in some patients, for acute otitis media transforming into chronic otitis media. The present study included 60 patients admitted to the Clinical Rehabilitation Hospital, Iasi, Romania, for surgery. The control group comprised 30 healthy individuals. Serum levels of interleukin 1 alpha (IL-1 alpha), interleukin 6 (IL-6) and interleukin 8 (IL-8) were measured prior to surgery and were compared among patients with chronic suppurative otitis media (CSOM), cholesteatoma and cholesteatoma recidivism and the control group. High serum levels of interleukins were recorded in all the groups compared to the healthy control group. IL-6 and IL-8 had the highest value in patients with CSOM and IL-1 alpha had the highest value in patients with cholesteatoma recidivism. Thus, we can consider that inflammatory mediators play a central role in the pathogenesis of CSOM and cholesteatoma by maintaining a systemic and local inflammatory response.

引用

页数：7

共 23 条

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