Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies

被引：206

作者：

Sole, Brisa ^{[1
]}

Jimenez, Esther ^{[1
]}

Torrent, Carla ^{[1
]}

Reinares, Maria ^{[1
]}

del Mar Bonnin, Caterina ^{[1
]}

Torres, Imma ^{[1
]}

Varo, Cristina ^{[1
]}

Grande, Iria ^{[1
]}

Valls, Elia ^{[1
]}

Salagre, Estela ^{[1
]}

Sanchez-Moreno, Jose ^{[1
]}

Martinez-Aran, Anabel ^{[1
]}

Carvalho, Andre F. ^{[2
]}

Vieta, Eduard ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin, Barcelona Bipolar Disorders Program, Inst Neurosci,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain

[2] Univ Fed Ceara, Fac Med, Translat Psychiat Res Grp, Fortaleza, Ceara, Brazil

来源：

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2017年 / 20卷 / 08期

关键词：

cognitive impairment; bipolar disorder; cognitive remediation; functional remediation; N-ACETYL CYSTEINE; DIRECT-CURRENT STIMULATION; MAJOR DEPRESSIVE DISORDER; DOUBLE-BLIND; EUTHYMIC PATIENTS; SOCIAL COGNITION; FUNCTIONAL REMEDIATION; NEUROCOGNITIVE FUNCTION; EXECUTIVE FUNCTIONS; ALCOHOL DEPENDENCE;

D O I：

10.1093/ijnp/pyx032

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Over the last decade, there has been a growing appreciation of the importance of identifying and treating cognitive impairment associated with bipolar disorder, since it persists in remission periods. Evidence indicates that neurocognitive dysfunction may significantly influence patients' psychosocial outcomes. An ever-increasing body of research seeks to achieve a better understanding of potential moderators contributing to cognitive impairment in bipolar disorder in order to develop prevention strategies and effective treatments. This review provides an overview of the available data from studies examining treatments for cognitive dysfunction in bipolar disorder as well as potential novel treatments, from both pharmacological and psychological perspectives. All these data encourage the development of further studies to find effective strategies to prevent and treat cognitive impairment associated with bipolar disorder. These efforts may ultimately lead to an improvement of psychosocial functioning in these patients.

引用

页码：670 / 680

页数：11

共 120 条

[1] Methylene blue treatment for residual symptoms of bipolar disorder: randomised crossover study [J].