Mobilization of hematopoietic stem cells

被引：55
作者：
Fu, S [1 ]
Liesveld, J [1 ]
机构：
[1] Univ Rochester, Med Ctr, Dept Internal Med, Hematol Oncol Blood & Marrow Transplant Program, Rochester, NY 14642 USA
来源：
BLOOD REVIEWS | 2000年 / 14卷 / 04期
关键词：
D O I：
10.1054/blre.2000.0138
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hematopoietic stem cell transplantation has been extensively exploited as a therapeutic and research modality and has revolutionized current patient care. At present, more and more medical centers use peripheral blood progenitor cells for transplantation by mobilizing hematopoietic stem cells from bone marrow to peripheral blood because of potential advantages of peripheral blood stem cell transplantation over bone-marrow transplantation. Different effective mobilization regimens have been developed recently with chemotherapeutic agents, hematopoietic growth factors or their combination. This article reviews current developments related to hematopoietic stem cell mobilization including the biology of hematopoietic stem cells, strategies for mobilization, management for mobilization failure, mechanisms of mobilization, and side effects during mobilization. Finally the Initiation-Amplification-Emigration-Adaptation Model is proposed to help aid understanding of the mechanisms of hematopoietic stem cell mobilization and to stimulate development of novel and optimal mobilization strategies for patient care. (C) 2000 Harcourt Publishers Ltd.
引用
收藏
页码：205 / 218
页数：14
相关论文
共 136 条
[1]  
Akard L P, 1999, Biol Blood Marrow Transplant, V5, P379, DOI 10.1016/S1083-8791(99)70014-5
[2]   The use of mobilized peripheral blood stem cells from normal donors for allografting [J].
Anderlini, P ;
Korbling, M .
STEM CELLS, 1997, 15 (01) :9-17
[3]  
Anderlini P, 1998, BONE MARROW TRANSPL, V21, pS35
[4]   Flow cytometry using annexin V can detect early apoptosis in peripheral blood stem cell harvests from patients with leukaemia and lymphoma [J].
Anthony, RS ;
McKelvie, ND ;
Cunningham, AJ ;
Craig, JIO ;
Rogers, SY ;
Parker, AC .
BONE MARROW TRANSPLANTATION, 1998, 21 (05) :441-446
[5]  
Atwater S, 1996, Curr Opin Hematol, V3, P71
[6]  
Avigan D, 1999, CLIN CANCER RES, V5, P2735
[7]   Rapid hematopoietic recovery after multicycle high-dose chemotherapy: Enhancement of filgrastim-induced progenitor-cell mobilization by recombinant human stem-cell factor [J].
Basser, RL ;
To, LB ;
Begley, CG ;
Maher, D ;
Juttner, C ;
Cebon, J ;
Mansfield, R ;
Olver, I ;
Duggan, G ;
Szer, J ;
Collins, J ;
Schwartz, B ;
Marty, J ;
Menchaca, D ;
Sheridan, WP ;
Fox, RM ;
Green, MD .
JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (05) :1899-1908
[8]  
Bearman S I, 1997, Curr Opin Hematol, V4, P157
[9]   Modulation of VLA-4 and L-selectin expression on normal CD34+ cells during mobilization with G-CSF [J].
Bellucci, R ;
De Propris, MS ;
Buccisano, F ;
Lisci, A ;
Leone, G ;
Tabilio, A ;
de Fabritiis, P .
BONE MARROW TRANSPLANTATION, 1999, 23 (01) :1-8
[10]   Mobilization of peripheral blood progenitor cells (PBPC) in patients undergoing chemotherapy followed by autologous peripheral blood stem cell transplant (SCT) for high risk breast cancer (HRBC) [J].
Benet, I ;
Prosper, F ;
Marugan, I ;
Lluch, A ;
Arbona, C ;
Castillo, I ;
Solano, C ;
Garcia-Conde, J .
BONE MARROW TRANSPLANTATION, 1999, 23 (11) :1101-1107
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