Type I natural killer T cells: naturally born for fighting

被引:8
|
作者
Tan, Jin-quan [1 ,2 ,3 ]
Xiao, Wei [1 ]
Wang, Lan [1 ]
He, Yu-ling [1 ,2 ,3 ]
机构
[1] Wuhan Univ, Sch Med, Dept Immunol, Wuhan 430071, Peoples R China
[2] Wuhan Univ, Sch Med, Lab Allergy & Clin Immunol, Inst Allergy & Immune Related Dis, Wuhan 430071, Peoples R China
[3] Wuhan Univ, Sch Med, Med Res Ctr, Wuhan 430071, Peoples R China
基金
中国国家自然科学基金;
关键词
NKT cells; tumor immunity; cell development and homeostasis; Th1/Th2; cytokines; NKT-CELL; DENDRITIC CELLS; IFN-GAMMA; CANCER-PATIENTS; THYMOCYTE SURVIVAL; INVARIANT; IMMUNITY; CD4(+); REQUIREMENT; ACTIVATION;
D O I
10.1038/aps.2010.119
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Type I natural killer T cells (NKT cells), a subset of CD1d-restricted T cells with invariant V alpha beta TCR, are characterized by prompt production of large amounts of Th1 and/or Th2 cytokines upon primary stimulation through the TCR complex. The rapid release of cytokines implies that type. NKT cells may play a critical role in modulating the upcoming immune responses, such as anti-tumor response, protection against infection, and autoimmunity. As a bridge between innate and adaptive immunity, type. NKT cells differentiate and mature upon stimulations to achieve and maintain a homeostasis. Orchestrating with other arms of adaptive immunity, type. NKT cells show strong cytotoxic effects in response to various tumors in a direct and/or indirect manner(s). This review will focus primarily on type. NKT cell development, homeostasis, and effector functions, especially in anti-tumor immunity, and followed by their potential applications in treatment of cancers.
引用
收藏
页码:1123 / 1132
页数:10
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