Discrimination between receptor- and store-operated Ca2+ influx in human neutrophils

被引：8

作者：

Salmon, Michael D. ^{[1
]}

Ahluwalia, Jatinder ^{[1
]}

机构：

[1] Univ E London, Leukocyte & Ion Channel Res Lab, Sch Hlth & Biosci, London E15 4LZ, England

来源：

CELLULAR IMMUNOLOGY | 2010年 / 265卷 / 01期

关键词：

Calcium; Strontium; 2-APB; Pyr3; Neutrophils; 2-AMINOETHOXYDIPHENYL BORATE; 2-AMINOETHYLDIPHENYL BORATE; TRPC3; CHANNELS; CALCIUM-ENTRY; INHIBITION; EXOCYTOSIS; OCCURS;

D O I：

10.1016/j.cellimm.2010.07.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ca2+ and Sr2+ entry pathways activated by pro-inflammatory agonists FMLP, LTB4 and PAF have been compared to thapsigargin in human neutrophils. 2-APB (10 mu M) increased Ca2+ influx and to a greater extent in agonist than in thapsigargin stimulated neutrophils. This action of 2-APB was specific to Ca2+ because 2-APB did not augment Sr2+ entry in agonist and thapsigargin stimulated neutrophils. This suggests that Ca2+ and Sr2+ entry can be used to discriminate between receptor and non-receptor (store)operated Ca2+ influx. Our data show for the first time that Pyr3 whilst partially inhibiting agonist induced Ca2+ influx almost completely abolished Ca2+ influx after thapsigargin stimulation. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1 / 5

页数：5

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