Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties

被引：48

作者：

Kela, J

Salmi, P

Rimondini-Giorgini, R

Heilig, M

Wahlestedt, C

机构：

[1] Karolinska Inst, Ctr Genom & Bioinformat, SE-17177 Stockholm, Sweden

[2] Huddinge Univ Hosp, Dept NEUROTEC, Karolinska Inst, SE-14186 Stockholm, Sweden

来源：

REGULATORY PEPTIDES | 2003年 / 114卷 / 2-3期

关键词：

food intake; anxiety; body temperature; thermoregulation; locomotor activity; exploratory behaviour;

D O I：

10.1016/S0167-0115(03)00114-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, predominantly expressed in hypothalamus, and recognized as a key regulator in feeding behaviour and energy balance. In this study, we examined the behavioural effects of intracerebroventricularly administered MCH on food intake, anxiety, exploratory behaviour and body core temperature in rats. MCH (0.15-10.0 mug, i.c.v.) acutely increased food intake in a dose-dependent manner. In addition, MCH (0.6-10.0 mug, i.c.v.) produced effects similar to anxiolytics in an animal model of anxiety, Vogel's punished drinking test. Thus, punished drinking episodes were significantly increased. We found no effects of MCH (5.0-20.0 mug, i.c.v.) on locomotor activity either in habituated or non-habituated animals. Furthermore, MCH did not produce any changes in body core temperature. Together, these observations further support a role for MCH as an orexigenic neuropeptide and also suggest anti-anxiety proper-ties for MCH. (C) 2003 Elsevier Science B.V. All rights reserved.

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页码：109 / 114

页数：6

相关论文

共 36 条

[1] Identification and characterization of a melanin-concentrating hormone receptor [J].

An, SZ ;

Cutler, G ;

Zhao, JJ ;

Huang, SG ;

Tian, H ;

Li, WB ;

Liang, LM ;

Rich, M ;

Bakleh, A ;

Du, J ;

Chen, JL ;

Dai, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (13) :7576-7581

[2] Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1) [J].

Bächner, D ;

Kreienkamp, HJ ;

Weise, C ;

Buck, F ;

Richter, D .

FEBS LETTERS, 1999, 457 (03) :522-524

[3] THE MELANIN-CONCENTRATING HORMONE SYSTEM OF THE RAT-BRAIN - AN IMMUNIZATION AND HYBRIDIZATION HISTOCHEMICAL CHARACTERIZATION [J].

BITTENCOURT, JC ;

PRESSE, F ;

ARIAS, C ;

PETO, C ;

VAUGHAN, J ;

NAHON, JL ;

VALE, W ;

SAWCHENKO, PE .

JOURNAL OF COMPARATIVE NEUROLOGY, 1992, 319 (02) :218-245

[4] Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist [J].

Borowsky, B ;

Durkin, MM ;

Ogozalek, K ;

Marzabadi, MR ;

DeLeon, J ;

Heurich, R ;

Lichtblau, H ;

Shaposhnik, Z ;

Daniewska, I ;

Blackburn, TP ;

Branchek, TA ;

Gerald, C ;

Vaysse, PJ ;

Forray, C .

NATURE MEDICINE, 2002, 8 (08) :825-830

[5] Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1 [J].

Chambers, J ;

Ames, RS ;

Bergsma, D ;

Muir, A ;

Fitzgerald, LR ;

Hervieu, G ;

Dytko, GM ;

Foley, JJ ;

Martin, J ;

Liu, WS ;

Park, J ;

Ellis, C ;

Ganguly, S ;

Konchar, S ;

Cluderay, J ;

Leslie, R ;

Wilson, S ;

Sarau, HM .

NATURE, 1999, 400 (6741) :261-265

[6] PHOTOCELL MEASUREMENTS OF RAT MOTOR-ACTIVITY - A CONTRIBUTION TO SENSITIVITY AND VARIATION IN BEHAVIORAL OBSERVATIONS [J].

ERICSON, E ;

SAMUELSSON, J ;

AHLENIUS, S .

JOURNAL OF PHARMACOLOGICAL METHODS, 1991, 25 (02) :111-122

[7] Cloning and characterization of rhesus monkey MCH-R1 and MCH-R2 [J].

Fried, S ;

O'Neill, K ;

Hawes, BE .

PEPTIDES, 2002, 23 (08) :1401-1408

[8] Behavioral effects of alpha-MSH and MCH after central administration in the female rat [J].

Gonzalez, MI ;

Vaziri, S ;

Wilson, CA .

PEPTIDES, 1996, 17 (01) :171-177

[9] The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat [J].

Hervieu, GJ ;

Cluderay, JE ;

Harrison, D ;

Meakin, J ;

Maycox, P ;

Nasir, S ;

Leslie, RA .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (04) :1194-1216

[10] Molecular cloning and functional characterization of MCH2, a novel human MCH receptor [J].

Hill, J ;

Duckworth, M ;

Murdock, P ;

Rennie, G ;

Sabido-David, C ;

Ames, RS ;

Szekeres, P ;

Wilson, S ;

Bergsma, DJ ;

Gloger, IS ;

Levy, DS ;

Chambers, JK ;

Muir, AI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (23) :20125-20129

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