The effect of season on cytokine expression in multiple sclerosis and healthy subjects

被引：22

作者：

Stewart, Niall

Taylor, Bruce

Ponsonby, Anne-Louise

Pittas, Fotini

van der Mei, Ingrid

Woods, Greg

Walters, Haydn

机构：

[1] Univ Tasmania, Sch Med, Hobart, Tas 7000, Australia

[2] Univ Otago, Christchurch Sch Med & Hlth Sci, Christchurch, New Zealand

[3] Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Brisbane, Qld, Australia

[4] Menzies Res Inst, Hobart, Tas, Australia

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 188卷 / 1-2期

关键词：

multiple sclerosis; cytokines; season;

D O I：

10.1016/j.jneuroim.2007.06.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We measured the levels of IFN-gamma, TNF alpha, I1-4 and I1-10 produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from healthy people, and those with the relapse/remitting fonn of multiple sclerosis. Blood was taken in summer and winter. Healthy people had a summer excess of I1-4, I1-10 and TNF alpha, and a winter excess of IFN-gamma. Untreated NIS cases had a summer excess of I1-10, whereas those treated with Interferon-beta had lower levels of all cytokines, and displayed no seasonal effect. Crown Copyright (c) 2007 Published by Elsevier B.V. All rights reserved.

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收藏

页码：181 / 186

页数：6

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