In evaluating explosion-protection capacity, safety distance is broadly accepted as the distance at which detonation of a given explosive causes acceptable structural damage. Safety distance can be calculated based on structural response under blast loading and damage criteria. For the applicability of the safety distance, the minimum required stand-off distance should be given when the explosive size is assumed. However, because of the nature of structures, structural details and material characteristics differ, which requires sensitivity analysis of the safety distance. This study examines the safety-distance sensitivity from structural and material property variations. For the safety-distance calculation, a blast analysis module based on the Kingery and Bulmash formula, a structural response module based on a Single Degree of Freedom model, and damage criteria based on a support rotation angle were prepared. Sensitivity analysis was conducted for the Reinforced Concrete one-way slab with different thicknesses, reinforcement ratios, reinforcement yield strengths, and concrete compressive strengths. It was shown that slab thickness has the most significant influence on both inertial force and flexure resistance, but the compressive strength of the concrete is not relevant.