Predictive Values of Preoperative Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Renal Mass: A Retrospective Study

Objective: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are easily accessible inflammatory parameters. In the present study, we aimed to analyze the coherence of these two markers for the predictive value of malignancy in patients with a kidney mass and histologic grade of patients with renal cell carcinoma (RCC). Materials and Methods: A total of 65 patients with a kidney mass (median age, 58; IQR, 47-68), who underwent either radical or partial nephrectomy, were included into this retrospective study. The NLR and PLR were derived from the complete blood cell count results at the preoperative period. Patients were divided in to two groups: as benign and malign. Also, patients with diagnosed RCC were further analyzed using the Fuhrman histologic grading. Results: A univariate regression analysis showed that the LnNLR (1.125, 95% confidence interval [CI] [1.00-31.26]; p=0.04) levels were significantly associated with RCC. However, the LnPLR levels did not show any significant association (5.32, 95% CI [0.46-60.8]; p=0.17). After adjusting the analysis for age and gender, only the LnNLR levels (1.14, 95% CI [1.01-1.30]; p=0.03) were still associated with RCC. The NLR levels showed a sequential increase from the low grade to high grade according to the Fuhrman grading system among RCC patients. Conclusion: Higher NLR levels were significantly associated with a malign kidney mass and high-grade RCC.