Inter-homologue repair in fertilized human eggs?

被引：67

作者：

Egli, Dieter ^{[1
,2
]}

Zuccaro, Michael V. ^{[3
]}

Kosicki, Michael ^{[4
]}

Church, George M. ^{[5
]}

Bradley, Allan ^{[4
]}

Jasin, Maria ^{[6
]}

机构：

[1] Columbia Univ, Dept Obstet & Gynecol, New York, NY 10027 USA

[2] Columbia Univ, Dept Pediat, New York, NY 10027 USA

[3] Columbia Univ, Dept Physiol & Cellular Biophys, Grad Program, New York, NY USA

[4] Wellcome Sanger Inst, Cambridge, England

[5] Harvard Med Sch, Dept Genet, Boston, MA USA

[6] Mem Sloan Kettering Canc Ctr, Dev Biol Program, 1275 York Ave, New York, NY 10021 USA

来源：

NATURE | 2018年 / 560卷 / 7717期

关键词：

HUMAN ZYGOTES; EMBRYOS; GENOME; BREAKS;

D O I：

10.1038/s41586-018-0379-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：E5 / E7

页数：3

共 16 条

[1] A QUANTITATIVE AND CYTOLOGICAL STUDY OF GERM CELLS IN HUMAN OVARIES [J].

BAKER, TG .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1963, 158 (972) :417-+

[2] Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics [J].

Cole, Francesca ;

Baudat, Frederic ;

Grey, Corinne ;

Keeney, Scott ;

de Massy, Bernard ;

Jasin, Maria .

NATURE GENETICS, 2014, 46 (10) :1072-1080

[3] Developmental reprogramming after chromosome transfer into mitotic mouse zygotes [J].

Egli, Dieter ;

Rosains, Jacqueline ;

Birkhoff, Garrett ;

Eggan, Kevin .

NATURE, 2007, 447 (7145) :679-U8

[4] Reprogramming within hours following nuclear transfer into mouse but not human zygotes [J].

Egli, Dieter ;

Chen, Alice E. ;

Saphier, Genevieve ;

Ichida, Justin ;

Fitzgerald, Claire ;

Go, Kathryn J. ;

Acevedo, Nicole ;

Patel, Jay ;

Baetscher, Manfred ;

Kearns, William G. ;

Goland, Robin ;

Leibel, Rudolph L. ;

Melton, Douglas A. ;

Eggan, Kevin .

NATURE COMMUNICATIONS, 2011, 2

[5] Intense and highly localized gene conversion activity in human meiotic crossover hot spots [J].

Jeffreys, AJ ;

May, CA .

NATURE GENETICS, 2004, 36 (02) :151-156

[6] Normal birth after microsurgical enucleation of tripronuclear human zygotes: Case report [J].

Kattera, S ;

Chen, C .

HUMAN REPRODUCTION, 2003, 18 (06) :1319-1322

[7] Numerical constraints and feedback control of double-strand breaks in mouse meiosis [J].

Kauppi, Liisa ;

Barchi, Marco ;

Lange, Julian ;

Baudat, Frederic ;

Jasin, Maria ;

Keeney, Scott .

GENES & DEVELOPMENT, 2013, 27 (08) :873-886

[8] Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements [J].

Kosicki, Michael ;

Tomberg, Kart ;

Bradley, Allan .

NATURE BIOTECHNOLOGY, 2018, 36 (08) :765-+

[9] Correction of a pathogenic gene mutation in human embryos (Publication with Expression of Concern) [J].

Ma, Hong ;

Marti-Gutierrez, Nuria ;

Park, Sang-Wook ;

Wu, Jun ;

Lee, Yeonmi ;

Suzuki, Keiichiro ;

Koski, Amy ;

Ji, Dongmei ;

Hayama, Tomonari ;

Ahmed, Riffat ;

Darby, Hayley ;

Van Dyken, Crystal ;

Li, Ying ;

Kang, Eunju ;

Park, A. -Reum ;

Kim, Daesik ;

Kim, Sang-Tae ;

Gong, Jianhui ;

Gu, Ying ;

Xu, Xun ;

Battaglia, David ;

Krieg, Sacha A. ;

Lee, David M. ;

Wu, Diana H. ;

Wolf, Don P. ;

Heitner, Stephen B. ;

Belmonte, Juan Carlos Izpisua ;

Mato, Paula A. ;

Kim, Jin-Soo ;

Kaul, Sanjiv ;

Mitalipov, Shoukhrat .

NATURE, 2017, 548 (7668) :413-+

[10] Detailed Phenotypic and Molecular Analyses of Genetically Modified Mice Generated by CRISPR-Cas9-Mediated Editing [J].

Parikh, Bijal A. ;

Beckman, Diana L. ;

Patel, Swapneel J. ;

White, J. Michael ;

Yokoyama, Wayne M. .

PLOS ONE, 2015, 10 (01)

← 1 2 →