Heart failure with preserved ejection fraction: Classification based upon phenotype is essential for diagnosis and treatment

被引：32
作者：
Xanthopoulos, Andrew [1 ,2 ]
Triposkiadis, Filippos [2 ]
Starling, Randall C. [1 ]
机构：
[1] Cleveland Clin, Dept Cardiovasc Med, Heart & Vasc Inst, Kaufman Ctr Heart Failure, 9500 Euclid Ave, Cleveland, OH 44195 USA
[2] Univ Gen Hosp Larissa, Dept Cardiol, Larisa, Greece
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2018年 / 28卷 / 06期
关键词：
Heart failure; Preserved ejection fraction; Phenotypes; Classification; GLOBAL LONGITUDINAL STRAIN; CORONARY-ARTERY-DISEASE; NITRIC OXIDE PATHWAY; REDUCE LAP-HF; VENTRICULAR DYSFUNCTION; EXERCISE HEMODYNAMICS; SCIENTIFIC STATEMENT; INORGANIC NITRATE; SYSTOLIC FUNCTION; CARDIAC-FUNCTION;
D O I：
10.1016/j.tcm.2018.01.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Heart failure (HF) is classified based upon the left ventricular ejection fraction (LVEF). Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disorder with increasing prevalence in the elderly that remains incompletely understood and inadequately treated as no therapy has shown favorable effects. In this review, we summarize the current theories regarding HFpEF pathogenesis, propose a phenotype-based classification of HFpEF, discuss prevention strategies, explain why clinical trials on HFpEF treatment have failed, and make suggestions for the future. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：392 / 400
页数：9
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