Stigmatization is common in patients with non-alcoholic fatty liver disease and correlates with quality of life

被引：27

作者：

Carol, Marta ^{[1
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,3
,4
]}

Perez-Guasch, Martina ^{[1
,2
,3
]}

Sola, Elsa ^{[1
,2
,3
,4
]}

Cervera, Marta ^{[1
,2
,3
,4
]}

Martinez, Sara ^{[1
,2
,3
]}

Juanola, Adria ^{[1
,2
,3
]}

Ma, Ann T. ^{[1
,2
,3
]}

Avitabile, Emma ^{[1
,2
,3
]}

Napoleone, Laura ^{[1
,2
,3
]}

Pose, Elisa ^{[1
,2
,3
]}

Graupera, Isabel ^{[1
,2
,3
]}

Honrubia, Maria ^{[4
]}

Korenjak, Marko ^{[5
]}

Torres, Ferran ^{[6
,7
]}

Gines, Pere ^{[1
,2
,3
,4
]}

Fabrellas, Nuria ^{[1
,2
,3
,4
]}

机构：

[1] Univ Barcelona, Hosp Clin Barcelona, Liver Unit, Barcelona, Catalonia, Spain

[2] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Catalonia, Spain

[3] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Catalonia, Spain

[4] Univ Barcelona, Sch Med & Hlth Sci, Barcelona, Catalonia, Spain

[5] European Liver Patients Assoc ELPA, Brussels, Belgium

[6] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Med Stat Core Facil, Barcelona, Catalonia, Spain

[7] Univ Autonoma Barcelona, Fac Med, Biostat Unit, Barcelona, Catalonia, Spain

来源：

PLOS ONE | 2022年 / 17卷 / 04期

关键词：

PERCEIVED STIGMA; HEPATITIS-C; BODY-WEIGHT; HEALTH; DISCRIMINATION; QUESTIONNAIRE; OBESITY; CLDQ;

D O I：

10.1371/journal.pone.0265153

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background and aimsStigmatization is a well-documented problem of some diseases. Perceived stigma is common in alcohol-related liver disease and hepatitis C, but little information exists on stigma in patients with non-alcoholic fatty liver disease (NAFLD). Aim of the study was to investigate frequency and characteristics of perceived stigma among patients with NAFLD. MethodsOne-hundred and ninety-seven patients seen at the liver clinic were included: a study group of 144 patients with NAFLD, 50 with cirrhosis (34 compensated, 16 decompensated), and a control group of 53 patients with alcohol-related cirrhosis. Demographic, clinical, and laboratory data were collected. Quality-of-life was assessed by chronic liver disease questionnaire (CLDQ). Perceived stigma was assessed using a specific questionnaire for patients with liver diseases categorized in 4 domains: stereotypes, discrimination, shame, and social isolation. ResultsPerceived stigma was common in patients with NAFLD (99 patients, 69%) and affected all 4 domains assessed. The frequency was slightly higher, yet not significant, in patients with NAFLD cirrhosis vs those without (72% vs 67%, respectively; p = 0.576). In patients without cirrhosis perceived stigma was unrelated to stage of disease, since frequency was similar in patients with no or mild fibrosis compared to those with moderate/severe fibrosis (66% vs 68%, respectively). There were no differences in perceived stigma between patients with compensated cirrhosis and these with decompensated cirrhosis. Among patients with cirrhosis, stigmatization was more common in alcohol-related vs NAFLD-cirrhosis, yet differences were only significant in two domains. In patients with NAFLD, perceived stigma correlated with poor quality-of-life, but not with demographic or clinical variables. ConclusionsPerceived stigmatization is common among patients with NAFLD independently of disease stage, is associated with impaired quality-of-life, and may be responsible for stereotypes, discrimination, shame, and social isolation, which may affect human and social rights of affected patients.

引用

页数：14

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