Nostofungicidine, an antifungal lipopeptide from the field-grown terrestrial blue-green alga Nostoc commune

被引：64

作者：

Kajiyama, S ^{[1
]}

Kanzaki, H

Kawazu, K

Kobayashi, A

机构：

[1] Osaka Univ, Grad Sch Engn, Dept Biotechnol, Osaka 5650871, Japan

[2] Okayama Univ, Fac Agr, Dept Agr Sci, Okayama 7000082, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 22期

关键词：

natural products; algae; antifungals; amine acid and derivatives;

D O I：

10.1016/S0040-4039(98)00573-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the course of our screening program for bioactive compounds, a novel lipopeptide, nostofungicidine (1), was isolated from the methanolic extract of a field-grown terrestrial blue-green alga, Nostoc commune. The structure of nostofungicidine was elucidated by chemical degradation and extensive NMR measurements including DQF-COSY, HOHAHA, HMBC, and ROESY techniques. Nostofungicidine contains a novel beta-amino acid 3-amino-6-hydroxy stearic acid (Ahs) in its structure. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3737 / 3740

页数：4

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