Fire acupuncture for mild to moderate knee osteoarthritis: a protocol for a randomized controlled pilot trial

被引：7

作者：

Fu, Yuan-Bo ^{[1
,2
]}

Li, Bin ^{[1
]}

Sun, San-Feng ^{[2
]}

Liu, Hui-Lin ^{[1
]}

Wang, Xin ^{[1
]}

Wang, Shao-Song ^{[1
]}

Zhang, Fan ^{[1
]}

Du, Xin ^{[1
]}

Ge, Du-Juan ^{[2
]}

Shang, Lei ^{[2
]}

Liang, Rui-Li ^{[2
]}

Wang, Li-Na ^{[2
]}

Yuan, Fang ^{[1
]}

Sun, Jing-Qing ^{[1
]}

Chen, Jun-Wei ^{[1
,3
]}

机构：

[1] Capital Med Univ, Dept Acupuncture & Moxibust, Beijing Hosp Tradit Chinese Med, Beijing Key Lab Acupuncture Neuromodulat, 23 Meishuguanhou St, Beijing 100010, Peoples R China

[2] Beijing Huairou Dist Hosp Tradit Chinese Med, 1 Houheng St, Beijing 101400, Peoples R China

[3] Beijing Univ Chinese Med, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China

来源：

TRIALS | 2019年 / 20卷 / 01期

关键词：

Knee Osteoarthritis; Fire Acupuncture; Basic health management; OUTCOMES; ARTHRITIS; THERAPY; PATIENT; HIP;

D O I：

10.1186/s13063-019-3744-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: Knee osteoarthritis (KOA) is one of the most common bone and joint diseases. As one of the main non-drug therapies, acupuncture is widely used to treat KOA, although the evidence for its efficacy is inconclusive. The objective of this pilot trial is to clarify the clinical efficacy and safety of fire acupuncture in the treatment of mild to moderate KOA and to provide high-quality data for further research. Methods/design: This study is a prospective randomized controlled pilot trial in which 120 patients with mild to moderate KOA will be randomly allocated in equal proportions to a fire acupuncture group or a general acupuncture group. They will receive acupuncture for six sessions over 2 weeks. The primary end point is success rate, which will be calculated based on the change from baseline of the pain and function scores in the Western Ontario and McMaster Universities Osteoarthritis Index at 4 weeks. Secondary end points include the proportion of patients achieving clinical improvement based on: (1) the OMERACT-OARSI responder criteria, (2) levels of matrix metalloproteinase 3, interleukin 1 beta, and tumor necrosis factor a in blood, and (3) a subjective efficacy evaluation from patients.

引用

页数：8

共 19 条

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