Race/Ethnicity Is Not Independently Associated with Risk of Adverse Waitlist Removal among Patients with HCC Exception Points

被引:1
作者
Goyes, Daniela [1 ]
Nsubuga, John Paul [2 ]
Medina-Morales, Esli [3 ]
Barba, Romelia [3 ]
Patwardhan, Vilas [3 ]
Saberi, Behnam [3 ]
Fricker, Zachary [3 ]
Bonder, Alan [3 ]
机构
[1] Macneal Mem Hosp, Dept Med, Loyola Med, Berwyn, IL 60402 USA
[2] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA
[3] Beth Israel Deaconess Med Ctr, Div Gastroenterol Hepatol & Nutr, Boston, MA 02215 USA
关键词
disparities; liver cancer; allocation; HEPATOCELLULAR-CARCINOMA; LIVER-TRANSPLANTATION; NONALCOHOLIC STEATOHEPATITIS; AFRICAN-AMERICANS; DISPARITIES; DISEASE; ACCESS; STAGE;
D O I
10.3390/jcm10245826
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
(1) Background: Since 2015, exception points have been awarded to appropriate candidates after six months of waitlist time to allow more equitable access to liver transplants regardless of hepatocellular carcinoma status. However, it remains unknown whether racial disparities in outcomes among waitlisted patients remain after the introduction of a 6-month waiting period for exception points. (2) Methods: Using the United Network for Organ Sharing database, we identified 2311 patients diagnosed with hepatocellular carcinoma listed for liver transplant who received exception points from 2015 to 2019. The outcome of interest was waitlist survival defined as the composite outcome of death or removal for clinical deterioration. Competing risk analysis was used to identify factors associated with death or removal for clinical deterioration. The final model adjusted for age, sex, race/ethnicity, blood type, diabetes, obesity, laboratory MELD score, tumor size, AFP, locoregional therapies, UNOS region, and college education. (3) Results: No difference was found in the risk of adverse waitlist removal among ethnic/racial groups.
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页数:8
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共 19 条
[1]   The Social Determinants of Health: It's Time to Consider the Causes of the Causes [J].
Braveman, Paula ;
Gottlieb, Laura .
PUBLIC HEALTH REPORTS, 2014, 129 :19-31
[2]   Racial Disparities in Liver Transplantation for Hepatocellular Carcinoma Are Not Explained by Differences in Comorbidities, Liver Disease Severity, or Tumor Burden [J].
Dakhoul, Lara ;
Gawrieh, Samer ;
Jones, Keaton R. ;
Ghabril, Marwan ;
McShane, Chelsey ;
Orman, Eric ;
Vilar-Gomez, Eduardo ;
Chalasani, Naga ;
Nephew, Lauren .
HEPATOLOGY COMMUNICATIONS, 2019, 3 (01) :52-62
[3]   Race: A critical factor in organ donation, patient referral and selection, and orthotopic liver transplantation? [J].
Eckhoff, DE ;
McGuire, BM ;
Young, CJ ;
Sellers, MT ;
Frenette, LR ;
Hudson, SL ;
Contreras, JL ;
Bynon, S .
LIVER TRANSPLANTATION AND SURGERY, 1998, 4 (06) :499-505
[4]   Clinical Features Associated with Survival Outcome in African-American Patients with Hepatocellular Carcinoma [J].
Estevez, Jacqueline ;
Yang, Ju Dong ;
Leong, Jennifer ;
Nguyen, Pauline ;
Giama, Nasra H. ;
Zhang, Ning ;
Ali, Hamdi A. ;
Lee, Mei-Hsuan ;
Cheung, Ramsey ;
Roberts, Lewis ;
Schwartz, Myron ;
Nguyen, Mindie H. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2019, 114 (01) :80-88
[5]   Changes in the Prevalence of Hepatitis C Virus Infection, Nonalcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients With Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation [J].
Goldberg, David ;
Ditah, Ivo C. ;
Saeian, Kia ;
Lalehzari, Mona ;
Aronsohn, Andrew ;
Gorospe, Emmanuel C. ;
Charlton, Michael .
GASTROENTEROLOGY, 2017, 152 (05) :1090-+
[6]  
Ha J, 2016, J CLIN GASTROENTEROL, V50, P423, DOI 10.1097/MCG.0000000000000448
[7]   Delayed Hepatocellular Carcinoma Model for End-Stage Liver Disease Exception Score Improves Disparity in Access to Liver Transplant in the United States [J].
Heimbach, Julie K. ;
Hirose, Ryutaro ;
Stock, Peter G. ;
Schladt, David P. ;
Xiong, Hui ;
Liu, Jiannong ;
Olthoff, Kim M. ;
Harper, Ann ;
Snyder, Jon J. ;
Israni, Ajay K. ;
Kasiske, Bertram L. ;
Kim, W. Ray .
HEPATOLOGY, 2015, 61 (05) :1643-1650
[8]   Disparities in Liver Transplantation Before and After Introduction of the MELD Score [J].
Moylan, Cynthia A. ;
Brady, Carla W. ;
Johnson, Jeffrey L. ;
Smith, Alastair D. ;
Tuttle-Newhall, Janet E. ;
Muir, Andrew J. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 300 (20) :2371-2378
[9]   Effect of Mandatory 6-Month Waiting Period on Waitlist and Transplant Outcomes in Patients With Hepatocellular Carcinoma [J].
Nagai, Shunji ;
Kitajima, Toshihiro ;
Yeddula, Sirisha ;
Salgia, Reena ;
Schilke, Randolph ;
Abouljoud, Marwan S. ;
Moonka, Dilip .
HEPATOLOGY, 2020, 72 (06) :2051-2062
[10]   Racial, Gender, and Socioeconomic Disparities in Liver Transplantation [J].
Nephew, Lauren D. ;
Serper, Marina .
LIVER TRANSPLANTATION, 2021, 27 (06) :900-912