Effect of solvents on stabilization of micro drug particles

被引：6

作者：

Desai, Chintal ^{[1
]}

Meng, Xiangxin ^{[1
]}

Yang, Dachuan ^{[2
]}

Wang, Xianqin ^{[3
]}

Akkunuru, Vamshi ^{[4
]}

Mitra, Somenath ^{[1
]}

机构：

[1] New Jersey Inst Technol, Dept Chem & Environm Sci, Newark, NJ 07102 USA

[2] Ethicon Res & Dev, Appl Sci & Technol, Somerville, NJ 08844 USA

[3] New Jersey Inst Technol, Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USA

[4] Beckman Coulter Inc, Particle Characterizat, Miami, FL USA

来源：

JOURNAL OF CRYSTAL GROWTH | 2011年 / 314卷 / 01期

基金：

美国国家科学基金会;

关键词：

Stability; Solvents; Antisolvent; Drug particles; Colloid; WATER-SOLUBLE DRUG; DISSOLUTION BEHAVIOR; CELLULOSE ETHERS; NANOPARTICLES; CRYSTALLIZATION; PRECIPITATION; DISPERSIONS; DELIVERY;

D O I：

10.1016/j.jcrysgro.2010.11.153

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

Antisolvent synthesis of micron scale Griseofulvin was carried out with simultaneous suspension stabilization under low power ultrasonic agitation. The organic solvent plays an important role because the supersaturation could be varied by using different solvents and the physicochemical characteristics of the suspension are also altered, which affects stability. In this study we present the effect of solvents on particle formation, polymorphism and stability of micron scale Griseofulvin formation in aqueous media. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：353 / 358

页数：6

共 31 条

[1]

Allen L.V., 2005, Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems, P336

[2]

AUGUSTIJNS P, 2007, SOLVENT SYSTEMS THEI, P55

[3]

BANKER GS, 2002, MODERN PHARM, V121, P240

[4] Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles [J].

Bilati, U ;

Allémann, E ;

Doelker, E .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2005, 24 (01) :67-75

[5] LASER RAMAN INVESTIGATION OF PHARMACEUTICAL SOLIDS - GRISEOFULVIN AND ITS SOLVATES [J].

BOLTON, BA ;

PRASAD, PN .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (07) :789-793

[6] Role of polymeric stabilizers for drug nanocrystal dispersions [J].

Choi, JY ;

Yoo, JY ;

Kwak, HS ;

Nam, BU ;

Lee, J .

CURRENT APPLIED PHYSICS, 2005, 5 (05) :472-474

[7] Morphology and growth control of griseofulvin recrystallized by compressed carbon dioxide as antisolvent [J].

De Gioannis, B ;

Jestin, P ;

Subra, P .

JOURNAL OF CRYSTAL GROWTH, 2004, 262 (1-4) :519-526

[8] FUNDAMENTALS OF CRYSTALLIZATION - KINETIC EFFECTS ON PARTICLE-SIZE DISTRIBUTIONS AND MORPHOLOGY [J].

DIRKSEN, JA ;

RING, TA .

CHEMICAL ENGINEERING SCIENCE, 1991, 46 (10) :2389-2427

[9] The adsorption of cellulose ethers in aqueous suspensions of pyrantel pamoate: effects on zeta potential and stability [J].

Duro, R ;

Alvarez, C ;

Martinez-Pacheco, R ;

Gomez-Amoza, JL ;

Concheiro, A ;

Souto, C .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 1998, 45 (02) :181-188

[10]

Elizalde O, 2000, PART PART SYST CHAR, V17, P236, DOI 10.1002/1521-4117(200012)17:5/6<236::AID-PPSC236>3.0.CO

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