Induction Chemotherapy in Head and Neck Squamous Cell Carcinoma: A Question of Belief

被引：17

作者：

Karabajakian, Andy ^{[1
]}

Gau, Max ^{[1
]}

Reverdy, Thibault ^{[1
]}

Neidhardt, Eve-Marie ^{[1
]}

Fayette, Jerome ^{[1
]}

机构：

[1] Ctr Lutte Canc Leon Berard, Rhone Alpes, F-69008 Lyon, France

来源：

CANCERS | 2019年 / 11卷 / 01期

关键词：

induction; larynx preservation; controversial; inconclusive; de-escalation; toxicity; high-risk; LOCALLY ADVANCED HEAD; LOCOREGIONALLY ADVANCED HEAD; PHASE-III TRIAL; UNRESECTABLE HEAD; HUMAN-PAPILLOMAVIRUS; LARYNX PRESERVATION; RANDOMIZED-TRIAL; CISPLATIN; DOCETAXEL; CANCER;

D O I：

10.3390/cancers11010015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Induction chemotherapy (IC) in locally advanced head and neck squamous cell carcinoma (LA HNSCC) has been used for decades. However, its role is yet to be clearly defined outside of larynx preservation. Patients with high risk of distant failure might potentially benefit from sequential treatment. It is now widely accepted that TPF (docetaxel, cisplatin, and fluorouracil) is the standard IC regimen. Essays that have compared this approach with the standard of care, concurrent chemoradiotherapy (CCRT), are mostly inconclusive. Radiotherapy (RT) can be used in the post-IC setting and be sensitized by chemotherapy or cetuximab. Again, no consensus exists but there seems to be trend in favor of potentiation by cisplatin. Less toxic schemes of IC are tested as toxicity is a major issue with TPF. IC might have an interesting role in human papilloma virus (HPV)-related LA HNSCC and lead to CCRT de-escalation.

引用

页数：10

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