Facile One-Pot Multi-Component Synthesis of Spirooxindoles and 3, 3′-Disubstituted Oxindoles via sp3 C-H Activation/Functionalization of Azaarenes

被引：4

作者：

Pathan, Mohsinkhan Y. ^{[1
]}

Chavan, Santosh S. ^{[1
]}

Shaikh, Taufeekaslam M. Y. ^{[1
]}

Thorat, Shridhar H. ^{[2
]}

Gonnade, Rajesh G. ^{[2
]}

Mulla, Shafeek A. R. ^{[1
]}

机构：

[1] CSIR Natl Chem Lab, Chem Engn & Proc Dev Div, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India

[2] CSIR Natl Chem Lab, Phys & Mat Chem Div, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India

来源：

CHEMISTRYSELECT | 2017年 / 2卷 / 28期

关键词：

3; 3'-disubstituted oxindoles; silica-supported dodecatungstophosphoric acid (DTP/SiO2) catalyst; sp(3) C-H activation/functionalization; spirooxindoles; azaarenes; N-SULFONYL ALDIMINES; BOND FUNCTIONALIZATION; ASYMMETRIC-SYNTHESIS; CHANNEL OPENERS; DERIVATIVES; ACTIVATION; AMINATION; CONSTRUCTION; TEMPERATURE; SCAFFOLDS;

D O I：

10.1002/slct.201701507

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel one-pot multicomponent reaction (MCR) protocol has been demonstrated for the first time for sustainable and facile synthesis of spirooxindoles and 3, 3 '-disubstituted oxindoles in an excellent yield via sp(3) C-H activation/functionalization of 2-methyl azaarenes and (2-azaaryl)methanes with isatin, active methylene compounds using eco-friendly heterogeneous, reusable silica-supported dodecatungstophosphoric acid (DTP/SiO2) catalyst.

引用

页码：9147 / 9152

页数：6

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