From transcriptional complexity to cellular phenotypes: Lessons from yeast

被引：2

作者：

Pelechano, Vicent ^{[1
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, SciLifeLab, POB 1031, S-17121 Solna, Sweden

来源：

YEAST | 2017年 / 34卷 / 12期

基金：

瑞典研究理事会;

关键词：

transcriptome; mRNA isoforms; alternative polyadenylation; Transcription start site; S; cerevisiae; NONCODING RNA; FUNCTIONAL GENOMICS; GENE-EXPRESSION; GLOBAL ANALYSIS; MESSENGER-RNAS; PLURIPOTENCY; DIVERSITY; DECAY; ACT;

D O I：

10.1002/yea.3277

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pervasive transcription has been reported in many eukaryotic organisms, revealing a highly interleaved transcriptome organization that involves thousands of coding and non-coding RNAs. However, to date, the biological impact of transcriptome complexity is still poorly understood. Here I will review how subtle variations of the transcriptome can lead to divergent cellular phenotypes by fine-tuning both its coding potential and regulation. I will discuss strategies that can be used to link molecular variations with divergent biological outcomes. Finally, I will explore the implication of transcriptional complexity for our understanding of gene expression in the context of cell-to-cell phenotypic variability. Copyright (c) 2017 John Wiley & Sons, Ltd.

引用

页码：475 / 482

页数：8

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