An efficient and chemoselective Cbz-protection of amines using silica-sulfuric acid at room temperature

被引：41

作者：

Gawande, Manoj B. ^{[2
]}

Polshettiwar, Vivek ^{[1
]}

Rajender, S. Varma B. ^{[1
]}

Jayaram, Radha V. ^{[2
]}

机构：

[1] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA

[2] Inst Chem Technol, Dept Chem, Bombay, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 46期

关键词：

Cbz-protection; silica-sulfuric acid; solvent-free; greener synthesis;

D O I：

10.1016/j.tetlet.2007.09.091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, facile, and chemoselective N-benzyloxycarbonylation of amines using silica-sulfuric acid that proceeds under solvent-free conditions at room temperature has been achieved. These reactions are applicable to a wide variety of primary (aliphatic and cyclic) secondary amines, amino alcohols, and heterocyclic amines. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：8170 / 8173

页数：4

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