Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis

被引：138
作者：
Dev, Kumlesh K. [1 ,2 ]
Mullershausen, Florian [3 ]
Mattes, Henri [2 ]
Kuhn, Rainer R. [2 ]
Bilbe, Graeme [2 ]
Hoyer, Daniel [2 ]
Mir, Anis [2 ]
机构：
[1] Natl Univ Ireland Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland
[2] Nova Pharmaceut, Novartis Inst BioMed Res, Dept Neurosci, Basel, Switzerland
[3] Nova Pharmaceut, Novartis Inst BioMed Res, Dept G Prot Coupled Receptors, Basel, Switzerland
来源：
PHARMACOLOGY & THERAPEUTICS | 2008年 / 117卷 / 01期
关键词：
sphingosine-1-phosphate; SIP receptor; FTY720 (fingolimod); central nervous system; multiple sclerosis;
D O I：
10.1016/j.pharmthera.2007.08.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Multiple sclerosis (MS) is an autoimmune, neurological disability with unknown etiology. The current therapies available for MS work by all immunomodulatory action, preventing T-cell- and macrophage-mediated destruction of brain-resident oligodendrocytes and axonal loss. Recently, FTY720 (fingolimod) was shown to significantly reduce relapse rates in MS patients and is currently in Phase III clinical trials. This drug attenuates trafficking of harmful T cells entering the brain by regulating sphingosine-1-phosphate (SIP) receptors. Here, we outline the direct roles that S I P receptors play in the central nervous system (CNS) and discuss additional modalities by which FTY720 may provide direct neuroprotection in MS. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：77 / 93
页数：17
相关论文
共 189 条
[1]   Astrocyte-endothelial interactions and blood-brain barrier permeability [J].
Abbott, NJ .
JOURNAL OF ANATOMY, 2002, 200 (06) :629-638
[2]   Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer.: Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer [J].
Albert, R ;
Hinterding, K ;
Brinkmann, V ;
Guerini, D ;
Müller-Hartwieg, C ;
Knecht, H ;
Simeon, C ;
Streiff, M ;
Wagner, T ;
Welzenbach, K ;
Zécri, F ;
Zollinger, M ;
Cooke, N ;
Francotte, E .
JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (16) :5373-5377
[3]   Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate [J].
Alemany, R ;
Kleuser, B ;
Ruwisch, L ;
Danneberg, K ;
Lass, H ;
Hashemi, R ;
Spiegel, S ;
Jakobs, KH ;
Heringdorf, DMZ .
FEBS LETTERS, 2001, 509 (02) :239-244
[4]   Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5 [J].
An, SZ ;
Zheng, YH ;
Bleu, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (01) :288-296
[5]   Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes [J].
Anelli, V ;
Bassi, R ;
Tettamanti, G ;
Viani, P ;
Riboni, L .
JOURNAL OF NEUROCHEMISTRY, 2005, 92 (05) :1204-1215
[6]   Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors [J].
Bassi, R ;
Anelli, V ;
Giussani, P ;
Tettamanti, G ;
Viani, P ;
Riboni, L .
GLIA, 2006, 53 (06) :621-630
[7]   The role of sphingosine and ceramide kinases in inflammatory responses [J].
Baumruker, T ;
Bornancin, F ;
Billich, A .
IMMUNOLOGY LETTERS, 2005, 96 (02) :175-185
[8]   Sphingosine-1-phosphate prevents tumor necrosis factor-α-mediated monocyte adhesion to aortic endothelium in mice [J].
Bolick, DT ;
Srinivasan, S ;
Kim, KW ;
Hatley, ME ;
Clemens, JJ ;
Whetzel, A ;
Ferger, N ;
Macdonald, TL ;
Davis, MD ;
Tsao, PS ;
Lynch, KR ;
Hedrick, CC .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (05) :976-981
[9]   Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction [J].
Brailoiu, E ;
Cooper, RL ;
Dun, NJ .
BRITISH JOURNAL OF PHARMACOLOGY, 2002, 136 (08) :1093-1097
[10]   The immune modulator FTY720 targets sphingosine 1-phosphate receptors [J].
Brinkmann, V ;
Davis, MD ;
Heise, CE ;
Albert, R ;
Cottens, S ;
Hof, R ;
Bruns, C ;
Prieschl, E ;
Baumruker, T ;
Hiestand, P ;
Foster, CA ;
Zollinger, M ;
Lynch, KR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (24) :21453-21457
12345678910