Contributions of the ex vivo human perfused placenta in the study of placental transfer of drugs

被引：4
作者：
Ceccaldi, P. -F. [1 ,2 ]
Mandelbrot, L. [3 ]
Farinotti, R. [2 ]
Forestier, F. [2 ]
Gil, S. [2 ]
机构：
[1] Univ Paris 07, Hop Beaujon, AP HP, GHU Nord,Serv Gynecol Obstet, F-92100 Clichy, France
[2] Univ Paris 11, Fac Pharm, EA2706, F-92296 Chatenay Malabry, France
[3] Univ Paris 07, Hop Louis Mourier, AP HP, GHU Nord,Serv Gynecol Obstet, F-92701 Colombes, France
来源：
JOURNAL DE GYNECOLOGIE OBSTETRIQUE ET BIOLOGIE DE LA REPRODUCTION | 2010年 / 39卷 / 08期
关键词：
Human placenta; Perfused placental lobule; Drugs; P-GLYCOPROTEIN; DEPENDENT TRANSFER; ANTIPYRINE; EXPRESSION; TRANSPORT; INDINAVIR; PASSAGE; FLOW;
D O I：
10.1016/j.jgyn.2010.06.010
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Perfused human placental lobule was developed during the 1970s Only this model respects the anatomical features of the human placenta This approach allows different technical conditions (concentrations of drugs) without ethical problems Limitations of this ex vivo model are detailed in this review, also its recent contributions in better understanding of placental passage of drugs (C) 2010 Elsevier Masson SAS All rights reserved
引用
收藏
页码：601 / 605
页数：5
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