PEGylated Inorganic Nanoparticles

被引：446
作者：
Karakoti, Ajay S. [2 ]
Das, Soumen [1 ]
Thevuthasan, Suntharampillai [2 ]
Seal, Sudipta [1 ,3 ]
机构：
[1] Univ Cent Florida, NanoSci & Technol Ctr, Orlando, FL 32816 USA
[2] PNNL, Environm & Mol Sci Lab, Richland, WA USA
[3] Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 09期
基金：
美国国家科学基金会;
关键词：
metal oxides; nanoparticles; nanotherapeutics; PEGylation; surface modification; IRON-OXIDE NANOPARTICLES; QUANTUM-DOT NANOPARTICLES; IN-VIVO BIODISTRIBUTION; GOLD NANOPARTICLES; POLYETHYLENE-GLYCOL; DRUG-DELIVERY; SURFACE FUNCTIONALIZATION; MAGNETIC NANOPARTICLES; COLLOIDAL DISPERSIONS; CELLULAR UPTAKE;
D O I：
10.1002/anie.201002969
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Application of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long-term stability, and attachment of selective functional groups. This Minireview describes the role of polyethylene glycol (PEG) in the surface modification of oxides and focuses on their biomedical applications. Such a PEGylation of surfaces provides "stealth" characteristics to nanomaterials otherwise identified as foreign materials by human body. The role of PEG as structure-directing agent in synthesis of oxides is also presented. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1980 / 1994
页数：15
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