PEGylated Inorganic Nanoparticles

被引：458

作者：

Karakoti, Ajay S. ^{[2
]}

Das, Soumen ^{[1
]}

Thevuthasan, Suntharampillai ^{[2
]}

Seal, Sudipta ^{[1
,3
]}

机构：

[1] Univ Cent Florida, NanoSci & Technol Ctr, Orlando, FL 32816 USA

[2] PNNL, Environm & Mol Sci Lab, Richland, WA USA

[3] Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 09期

基金：

美国国家科学基金会;

关键词：

metal oxides; nanoparticles; nanotherapeutics; PEGylation; surface modification; IRON-OXIDE NANOPARTICLES; QUANTUM-DOT NANOPARTICLES; IN-VIVO BIODISTRIBUTION; GOLD NANOPARTICLES; POLYETHYLENE-GLYCOL; DRUG-DELIVERY; SURFACE FUNCTIONALIZATION; MAGNETIC NANOPARTICLES; COLLOIDAL DISPERSIONS; CELLULAR UPTAKE;

D O I：

10.1002/anie.201002969

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Application of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long-term stability, and attachment of selective functional groups. This Minireview describes the role of polyethylene glycol (PEG) in the surface modification of oxides and focuses on their biomedical applications. Such a PEGylation of surfaces provides "stealth" characteristics to nanomaterials otherwise identified as foreign materials by human body. The role of PEG as structure-directing agent in synthesis of oxides is also presented. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1980 / 1994

页数：15

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