New methodology for 2-alkylation of 3-furoic acids: application to the synthesis of tethered UC-781/d4T bifunctional HIV reverse-transcriptase inhibitors

被引：8

作者：

Arnott, G ^{[1
]}

Hunter, R ^{[1
]}

Mbeki, L ^{[1
]}

Mohamed, E ^{[1
]}

机构：

[1] Univ Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 23期

关键词：

furan alkylation; Wittig reaction of 2-furanylphosphonium salt; alkylated-UC-781; bifunctional HIV reverse-transcriptase inhibitors;

D O I：

10.1016/j.tetlet.2005.04.034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New methodology for 2-alkylation of 3-furoic acids is presented involving Wittig reactions of the 3-methoxycarbonyl-2-furanylmethylphosphonium salt. The methodology has been used to prepare a tethered 2-alkylated-UC-781/d4T conjugate as a potentially new type of HIV reverse-transcriptase inhibitor. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：4023 / 4026

页数：4

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