Effects of central endothelin-1 in normotensive and spontaneously hypertensive rats

被引：1
|
作者：
Ponomareva, TI [1 ]
Khokhlova, ON [1 ]
Tukhovskaya, EA [1 ]
Murashov, AM [1 ]
机构：
[1] Russian Acad Sci, Pushchino Branch, Lab Biol Tests, MM Shemyakin & Yu A Ovchinnikov Inst Bioorgan Che, Pushchino 142292, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 135卷 / 03期
关键词：
endothelin-1; rostroventrolateral medulla oblongata; sympathetic activity; ETB-receptors; ETA-receptors; spontaneously hypertensive rats;
D O I：
10.1023/A:1024172611834
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Changes in blood pressure and sympathetic nerve activity induced by local injection of endothelin-1 into the rostroventrolateral medulla were studied in narcotized stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive WKY rats. Endothelin-1 produced similar biphasic response in both rat strains: a transient increase in blood pressure and sympathetic nerve activity followed by progressive hypotension and bradycardia. Pretreatment with ETB-receptor antagonist BQ788 inhibited sympathetic activation induced by endothelin-1, while pretreatment with the ETA-receptor antagonist N-acetyl-[D-Trp(16)]-endothelin-1 abolished the subsequent hypotension. The antihypotensive effect of ETA-receptor blockade was most effective in normotensive rats. Our findings suggest that cardiovascular disorders in SHRSP rats can be related to peculiarities in the rostroventrolateral medullar endothelin system.
引用
收藏
页码：237 / 240
页数：4
相关论文
共 50 条
  • [41] Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats
    Yamaguchi, Shohei
    Matsumoto, Kento
    Wang, Wenhao
    Nakamura, Kozo
    FOODS, 2021, 10 (09)
  • [42] Effects of endothelin-1 on norepinephrine-induced vasoconstriction in deoxycorticosterone acetate salt hypertensive rats
    Kita, S
    Taguchi, Y
    Chatani, S
    Matsumura, Y
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 344 (01) : 53 - 57
  • [43] Reactivity of mesenteric arteries from fructose hypertensive rats to endothelin-1
    Verma, S
    Skarsgard, P
    Bhanot, S
    Yao, LF
    Laher, I
    McNeill, JH
    AMERICAN JOURNAL OF HYPERTENSION, 1997, 10 (09) : 1010 - 1019
  • [44] Responsiveness of aortic rings of cadmium-hypertensive rats to endothelin-1
    Ozdem, SS
    Ogutman, C
    PHARMACOLOGY, 1997, 54 (06) : 328 - 332
  • [45] In vivo effects of partial phosphorothioated AT1 receptor antisense oligonucleotides in spontaneously hypertensive and normotensive rats
    Piegari, E
    Galderisi, U
    Berrino, L
    Di Bernardo, G
    Cipollaro, M
    Esposito, F
    Rossi, F
    Cascino, A
    LIFE SCIENCES, 2000, 66 (21) : 2091 - 2099
  • [46] Vascular endothelin-1 expression and effect of an endothelin ETA antagonist on structure and function of small arteries from stroke-prone spontaneously hypertensive rats
    Sharifi, AM
    He, G
    Touyz, RM
    Schiffrin, EL
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1998, 31 : S309 - S312
  • [47] Endothelin and blood pressure in pregnant, spontaneously hypertensive rats
    Katz, A
    Peleg, E
    Kariv, N
    Rosenthal, T
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1999, 60 (03): : 154 - 160
  • [48] CARDIOVASCULAR EFFECTS OF CENTRALLY ADMINISTERED ENDOTHELIN-1 IN RATS
    GULATI, A
    REBELLO, S
    ROY, S
    SAXENA, PR
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1995, 26 : S244 - S246
  • [49] HEPARIN SUPPRESSES ENDOTHELIN-1 PEPTIDE AND MESSENGER-RNA EXPRESSION IN CULTURED ENDOTHELIAL-CELLS OF SPONTANEOUSLY HYPERTENSIVE RATS
    YOKOKAWA, K
    KOHNE, M
    MANDAL, AK
    TAHARA, H
    YANAGISAWA, M
    TAKEDA, T
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1994, 4 (09): : 1683 - 1689
  • [50] Endothelin-1 upregulation in the kidney of uninephrectomized spontaneously hypertensive rats and its modification by the angiotensin-converting enzyme inhibitor quinapril
    Largo, R
    GomezGarre, D
    Liu, XH
    Alonso, J
    Blanco, J
    Plaza, JJ
    Egido, J
    HYPERTENSION, 1997, 29 (05) : 1178 - 1185
12345