Effects of central endothelin-1 in normotensive and spontaneously hypertensive rats

被引：1
|
作者：
Ponomareva, TI [1 ]
Khokhlova, ON [1 ]
Tukhovskaya, EA [1 ]
Murashov, AM [1 ]
机构：
[1] Russian Acad Sci, Pushchino Branch, Lab Biol Tests, MM Shemyakin & Yu A Ovchinnikov Inst Bioorgan Che, Pushchino 142292, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 135卷 / 03期
关键词：
endothelin-1; rostroventrolateral medulla oblongata; sympathetic activity; ETB-receptors; ETA-receptors; spontaneously hypertensive rats;
D O I：
10.1023/A:1024172611834
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Changes in blood pressure and sympathetic nerve activity induced by local injection of endothelin-1 into the rostroventrolateral medulla were studied in narcotized stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive WKY rats. Endothelin-1 produced similar biphasic response in both rat strains: a transient increase in blood pressure and sympathetic nerve activity followed by progressive hypotension and bradycardia. Pretreatment with ETB-receptor antagonist BQ788 inhibited sympathetic activation induced by endothelin-1, while pretreatment with the ETA-receptor antagonist N-acetyl-[D-Trp(16)]-endothelin-1 abolished the subsequent hypotension. The antihypotensive effect of ETA-receptor blockade was most effective in normotensive rats. Our findings suggest that cardiovascular disorders in SHRSP rats can be related to peculiarities in the rostroventrolateral medullar endothelin system.
引用
收藏
页码：237 / 240
页数：4
相关论文
共 50 条
  • [31] Role of endothelin-1 in congestive gastropathy in portal hypertensive rats
    Migoh, S
    Hashizume, M
    Tsugawa, K
    Tanoue, K
    Sugimachi, K
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2000, 15 (02) : 142 - 147
  • [32] CHANGES IN THE CONCENTRATION OF ENDOTHELIN-1 DURING DEVELOPMENT OF HYPERTENSIVE RATS
    IYER, RS
    SINGH, G
    REBELLO, S
    ROY, S
    BHAT, R
    VIDYASAGAR, D
    GULATI, A
    PHARMACOLOGY, 1995, 51 (02) : 96 - 104
  • [33] CHARACTERISTICS OF ENDOTHELIN RECEPTORS IN THE CENTRAL-NERVOUS-SYSTEM OF SPONTANEOUSLY HYPERTENSIVE RATS
    GULATI, A
    REBELLO, S
    NEUROPHARMACOLOGY, 1992, 31 (03) : 243 - 250
  • [34] The effects of angiotensin II, endothelin-1, and protein kinase C inhibitor on DNA synthesis and intracellular calcium mobilization in vascular smooth muscle cells from young normotensive and spontaneously hypertensive rats
    Rosen, B
    Barg, J
    Zimlichman, R
    AMERICAN JOURNAL OF HYPERTENSION, 1999, 12 (12) : 1243 - 1251
  • [35] DIRECT RENAL EFFECTS OF ENDOTHELIN IN CHRONIC HYPOXIC SPONTANEOUSLY HYPERTENSIVE RATS
    CHEN, CF
    CHIEN, CT
    WU, MS
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1992, 19 (12) : 809 - 813
  • [36] Effects of bradykinin and icatibant on renal hemodynamics in conscious spontaneously hypertensive and normotensive rats
    Braun, C
    Ade, M
    Unger, T
    vanderWoude, FJ
    Rohmeiss, P
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1997, 30 (04) : 446 - 454
  • [37] LEUKOCYTE COUNTS AND ACTIVATION IN SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE RATS
    SCHMIDSCHONBEIN, GW
    SEIFFGE, D
    DELANO, FA
    SHEN, K
    ZWEIFACH, BW
    HYPERTENSION, 1991, 17 (03) : 323 - 330
  • [38] EFFECTS OF DUP 753 ON RENAL-FUNCTION OF NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS
    FENOY, FJ
    MILICIC, I
    SMITH, RD
    WONG, PC
    TIMMERMANS, PBMWM
    ROMAN, R
    AMERICAN JOURNAL OF HYPERTENSION, 1991, 4 (04) : S321 - S326
  • [39] SENSITIVITY AND REACTIVITY TO ENDOTHELIN-1 IN MESENTERIC BEDS AND AORTIC RINGS OF 4-WEEK-OLD SPONTANEOUSLY HYPERTENSIVE RATS
    CRISCIONE, L
    THOMANN, H
    LUU, TD
    CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1992, 14 (03) : 453 - 467
  • [40] DECREASED DENSITY OF ENDOTHELIN-1 BINDING-SITES IN AORTIC SMOOTH-MUSCLE CELLS OF SPONTANEOUSLY HYPERTENSIVE RATS
    ZANIN, L
    ROSSI, G
    PAULETTO, P
    TONELLO, M
    CARGNELLI, G
    PESSINA, AC
    JOURNAL OF HYPERTENSION, 1991, 9 : S190 - S191
12345