Effects of central endothelin-1 in normotensive and spontaneously hypertensive rats

被引：1
|
作者：
Ponomareva, TI [1 ]
Khokhlova, ON [1 ]
Tukhovskaya, EA [1 ]
Murashov, AM [1 ]
机构：
[1] Russian Acad Sci, Pushchino Branch, Lab Biol Tests, MM Shemyakin & Yu A Ovchinnikov Inst Bioorgan Che, Pushchino 142292, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 135卷 / 03期
关键词：
endothelin-1; rostroventrolateral medulla oblongata; sympathetic activity; ETB-receptors; ETA-receptors; spontaneously hypertensive rats;
D O I：
10.1023/A:1024172611834
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Changes in blood pressure and sympathetic nerve activity induced by local injection of endothelin-1 into the rostroventrolateral medulla were studied in narcotized stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive WKY rats. Endothelin-1 produced similar biphasic response in both rat strains: a transient increase in blood pressure and sympathetic nerve activity followed by progressive hypotension and bradycardia. Pretreatment with ETB-receptor antagonist BQ788 inhibited sympathetic activation induced by endothelin-1, while pretreatment with the ETA-receptor antagonist N-acetyl-[D-Trp(16)]-endothelin-1 abolished the subsequent hypotension. The antihypotensive effect of ETA-receptor blockade was most effective in normotensive rats. Our findings suggest that cardiovascular disorders in SHRSP rats can be related to peculiarities in the rostroventrolateral medullar endothelin system.
引用
收藏
页码：237 / 240
页数：4
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