Nitrostyrenes as 1,4-CCNO-dipoles: diastereoselective formal [4+1] cycloaddition of indoles

被引：15
作者：
Aksenov, Alexander V. [1 ]
Aksenov, Nicolai A. [1 ]
Aksenov, Dmitrii A. [1 ]
Khamraev, Vladislav F. [1 ]
Rubin, Michael [1 ,2 ]
机构：
[1] North Caucasus Fed Univ, Dept Chem, 1a Pushkin St, Stavropol 355009, Russia
[2] Univ Kansas, Dept Chem, 1251 Wescoe Hall Dr, Lawrence, KS 66045 USA
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 94期
基金：
俄罗斯科学基金会;
关键词：
EFFICIENT SYNTHESIS; BENZOXAZOLES; OXINDOLES; ROUTE;
D O I：
10.1039/c8cc07451h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An unusual reactivity of nitrostyrenes in phosphorous acid was discovered, which permits the employment of these readily available synthons as 1,4-CCNO-dipole surrogates in a highly diastereoselective (4+1)-cycloaddition of indoles to afford 4H-spiro[indole-3,5-isoxazoles] in a diastereomerically pure form.
引用
收藏
页码：13260 / 13263
页数：4
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