cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)

被引：189
作者：
Kiuchi, Y
Suzuki, H
Hirohashi, T
Tyson, CA
Sugiyama, Y [1 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
[2] SRI Int, Toxicol & Metab Lab, Menlo Pk, CA 94025 USA
来源：
FEBS LETTERS | 1998年 / 433卷 / 1-2期
关键词：
multidrug resistance associated protein; canalicular multispecific organic anion transporter; GS-X pump; multidrug resistance; biliary excretion;
D O I：
10.1016/S0014-5793(98)00899-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Previously, we cloned rat MRP3 as a candidate for an inducible transporter for the biliary excretion of organic anions [Hirohashi et al, (1998) Mol. Pharmacol, 53, 1068-1075]. in the present study, we cloned human MRP3 (1527 amino acids) from Caco-2 cells, Human MRP3 is predominantly expressed in liver, small intestine and colon; hepatic expression of MRP3 mas observed in humans but not in normal rats. In HepG2 cells, the expression of MRP3 was induced by phenobarbital, These results suggest that MRP3 may act as an inducible transporter in the biliary and intestinal excretion of organic anions, (C) 1998 Federation of European Biochemical Societies.
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页码：149 / 152
页数：4
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