Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity

被引:12
|
作者
D'Alessandro, Annamaria [1 ]
Di Felice, Giovina [1 ]
Manco, Melania [2 ]
Pastore, Anna [3 ]
Pezzi, Simona [1 ]
Mariani, Michela [4 ]
Fintini, Danilo [4 ]
Muda, Andrea Onetti [3 ]
Porzio, Ottavia [1 ,5 ]
机构
[1] IRCCS Bambino Gesu Childrens Hosp, Clin Biochem Lab, I-00165 Rome, Italy
[2] IRCCS Bambino Gesu Childrens Hosp, Res Unit Multifactorial & Complexes Phenotype Dis, I-00165 Rome, Italy
[3] IRCCS Bambino Gesu Childrens Hosp, Res Unit Diagnost & Management Innovat, I-00165 Rome, Italy
[4] IRCCS Bambino Gesu Childrens Hosp, Univ Pediat Clin Dept, Endocrinol Unit, I-00165 Rome, Italy
[5] Tor Vergata Univ, Dept Expt Med, I-00133 Rome, Italy
关键词
obesity; oxidative stress; thiols; glutathione; INSULIN-RESISTANCE; THIOL/DISULPHIDE HOMEOSTASIS; GLUTATHIONE SYNTHESIS; HOMOCYSTEINE; CYSTEINE; ACID; GLYCINE; WEIGHT; PLASMA;
D O I
10.3390/nu14173637
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Obesity has reached epidemic proportions, and the World Health Organization defined childhood overweight and obesity as a noncommunicable disease that represents the most serious public health challenges of the twenty-first century. Oxidative stress, defined as an imbalance between oxidants and antioxidants causing an impairment of the redox signals, is linked to the development of metabolic diseases. In addition, reactive oxygen species generated during metabolic disorder could increase inflammation, causing the development of insulin resistance, diabetes, and cardiovascular disease. We analyze serum levels of cysteine (Cys), cysteinyl-glycine (Cys-Gly), homocysteine (Hcy), and glutathione (GSH), and other markers of oxidative stress, such as thiobarbituric acid reactive substances (T-BARS), 8-isoprostane, and protein carbonyl in our children with obesity. Total antioxidant status was also determined. We found lower GSH and Cys-Gly levels, and higher Hcy and oxidative stress markers levels. We also found a positive correlation between Body Mass Index (BMI), Cys, GSH, and Hcy levels, between insulin and Cys levels, and between BMI and the homeostasis model assessment-estimated insulin resistance (HOMA-IR) with 8-isoprostane levels. Finally, we found a correlation between age and GSH and Cys levels. The deficiency of GSH could be restored by dietary supplementation with GSH precursors, supplying an inexpensive approach to oppose oxidative stress, thus avoiding obesity complications.
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页数:10
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