Immune cell compartmentalization for brain surveillance and protection

被引:123
作者
Croese, Tommaso [1 ]
Castellani, Iulia [1 ]
Schwartz, Michal [1 ]
机构
[1] Weizmann Inst Sci, Dept Neurobiol, Rehovot, Israel
基金
欧洲研究理事会; 以色列科学基金会;
关键词
CENTRAL-NERVOUS-SYSTEM; REGULATORY T-CELLS; MULTIPLE-SCLEROSIS LESIONS; I INTERFERON RESPONSE; CHOROID-PLEXUS; DENDRITIC CELLS; MAST-CELLS; PERIVASCULAR MACROPHAGES; CEREBROSPINAL-FLUID; ANIMAL-MODEL;
D O I
10.1038/s41590-021-00994-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Schwartz and colleagues review the immune niches in the brain, the contribution of professional immune cells to brain functions and the relevance of immune components to brain aging and neurodegenerative disease. For decades, it was commonly accepted that the brain is secluded from peripheral immune activity and is self-sufficient for its maintenance and repair. This simplistic perception was based on the presence of resident immune cells, the microglia, and barrier systems within the brain, and the assumption that the central nervous system (CNS) lacks lymphatic drainage. This view was revised with the discoveries that higher functions of the CNS, homeostasis and repair are supported by peripheral innate and adaptive immune cells. The findings of bone marrow-derived immune cells in specialized niches, and the renewed observation that a lymphatic drainage system exists within the brain, further contributed to this revised model. In this Review, we describe the immune niches within the brain, the contribution of professional immune cells to brain functions, the bidirectional relationships between the CNS and the immune system and the relevance of immune components to brain aging and neurodegenerative diseases.
引用
收藏
页码:1083 / 1092
页数:10
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