Intraocular Exosomes in Eye Diseases

被引：10

作者：

Zhang, Hui ^{[1
,2
]}

Zhang, Xiaomin ^{[1
,2
]}

Li, Xiaorong ^{[1
,2
]}

机构：

[1] Tianjin Med Univ, Natl Clin Res Ctr Ocular Dis, Tianjin Key Lab Retinal Funct & Dis, Eye Inst,Tianjin Branch,Eye Hosp, Tianjin, Peoples R China

[2] Tianjin Med Univ, Sch Optometry, Eye Hosp, Tianjin, Peoples R China

来源：

CURRENT MOLECULAR MEDICINE | 2022年 / 22卷 / 06期

关键词：

Exosomes; aqueous humor; vitreous humor; glaucoma; age-related macular degeneration; extracellular vesicles; TRABECULAR MESHWORK CELLS; AQUEOUS-HUMOR; MACULAR DEGENERATION; MESENCHYMAL TRANSITION; EXTRACELLULAR VESICLES; COMPLEMENT PATHWAY; PROTEOMIC ANALYSIS; MYOCILIN; BIOMARKERS; OUTFLOW;

D O I：

10.2174/1566524021666210901122948

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Exosomes, nanosized extracellular vesicles with a size of 30-150nm, contain many biological materials, such as messenger RNA (mRNA), microRNA (miRNA), proteins, and transcription factors. It has been identified in all biological fluids and recognized as an important part of intercellular communication. While the role of exosomes in cancer has been studied in-depth, our understanding of their relevance for ocular tissues has just begun to evolve. Intraocular fluids, including aqueous humor and vitreous humor, play a role in nourishing eye tissues and in expelling metabolites. In the pathological state, intraocular exosomes can mediate pathological processes such as ECM remodeling, retinal inflammation, and blood-retinal barrier dysfunction. Herein, we reviewed the latest advances of intraocular exosomes in the research of several eye diseases, including glaucoma, age-related macular degeneration, myopia, and ocular tumors, and discuss how intraocular exosomes contribute to the pathogenesis and progression of multiple eye diseases.

引用

页码：540 / 548

页数：9

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