Measurement of activin B in human saliva and localization of activin subunits in rat salivary glands

被引:15
作者
Blauer, M [1 ]
Wichmann, L [1 ]
Punnonen, R [1 ]
Tuohimaa, P [1 ]
机构
[1] TAMPERE UNIV HOSP,DEPT OBSTET & GYNECOL,FIN-33101 TAMPERE,FINLAND
关键词
D O I
10.1006/bbrc.1996.0727
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The present paper is the first report to demonstrate that measurable amounts of activin B are secreted into the saliva. The results show wide fluctuations in activin B concentrations during the menstrual cycle with peak values detected at the follicular phase. Estrogen replacement therapy was found to increase salivary activin B levels in post-menopausal subjects. The concentration in males was negligible. These data suggest that activin B concentrations in the human saliva may be under hormonal regulation and propose that salivary activin B measurements may prove useful in investigating the as yet less well defined local and/or physiological roles of activin B. The present paper reports, in addition, the immunohistochemical localization of activin/inhibin subunits in the duct systems of the rat submandibular, sublingual and parotid salivary glands. (C) 1996 Academic Press, inc.
引用
收藏
页码:230 / 235
页数:6
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