The effects of vigabatrin on spike and wave discharges in WAG/Rij rats

被引：24
作者：
Bouwman, Brigitte M.
Suffczynski, Piotr
Midzyanovskaya, Inna S.
Maris, Eric
van den Broek, Philip L. C.
van Rijn, Clementina M.
机构：
[1] Radboud Univ Nijmegen, NICI, Dept Biol Psychol, NL-6500 HE Nijmegen, Netherlands
[2] Dutch Epilepsy Clin Fdn, Heemstede, Netherlands
[3] Warsaw Univ, Inst Expt Phys, Lab Med Phys, Warsaw, Poland
[4] Univ Warsaw, Inst Expt Phys, Lab Biomed Phys, PL-00681 Warsaw, Poland
[5] Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Moscow, Russia
[6] Radboud Univ Nijmegen, FC Donders Ctr Cognit Neuroimaging, NL-6500 HB Nijmegen, Netherlands
来源：
EPILEPSY RESEARCH | 2007年 / 76卷 / 01期
关键词：
Vigabatrin; GABA; spike wave; discharges; WAG/Rij rats; hazard rate; absence epilepsy;
D O I：
10.1016/j.eplepsyres.2007.06.006
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The effects of vigabatrin, which increases GABA concentrations by inhibiting GABA transaminase, on spike and wave discharges (SWDs) in the electroencephalogram of WAG/Rij rats were studied. Vigabatrin increased the incidence and duration of the SWDs, suggesting a quantitative GABA(A)ergic involvement in the mechanism(s) underlying the starting and stopping of an ongoing SWD. Also, vigabatrin decreased the SWD peak frequency, suggesting an important role of GABA(B) in the mechanism(s) underlying the peak frequency of the SWDs. Vigabatrin gradually changed the course of the hazard rates of the SWD durations, suggesting a quatitative GABAergic role in the mechanism(s) underlying the stopping of an ongoing SWD. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：34 / 40
页数：7
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