Stereoselective Synthesis of Cyclohexanes via an Iridium Catalyzed (5+1) Annulation Strategy

被引：66

作者：

Akhtar, Wasim M. ^{[1
]}

Armstrong, Roly J. ^{[1
]}

Frost, James R. ^{[1
]}

Stevenson, Neil G. ^{[2
]}

Donohoe, Timothy J. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

[2] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 38期

基金：

英国工程与自然科学研究理事会;

关键词：

HYDROGEN BORROWING CATALYSIS; CARBONYL-COMPOUNDS; C-H; ALCOHOLS; ALKYLATION; AMINES; DEHYDROGENATION; CARBOCYCLES; CARBANIONS; ACCESS;

D O I：

10.1021/jacs.8b07776

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An iridium catalyzed method for the synthesis of functionalized cyclohexanes from methyl ketones and 1,5-diols is described. This process operates by two sequential hydrogen borrowing reactions, providing direct access to multisubstituted cyclic products with high levels of stereocontrol. This methodology represents a novel (5 + 1) strategy for the stereoselective construction of the cyclohexane core.

引用

页码：11916 / 11920

页数：5

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