The Genome 10K Project: A Way Forward

被引：238

作者：

Koepfli, Klaus-Peter ^{[1
]}

Paten, Benedict ^{[2
]}

O'Brien, Stephen J. ^{[1
,3
]}

机构：

[1] St Petersburg State Univ, Theodosius Dobzhansky Ctr Genome Bioinformat, St Petersburg 199034, Russia

[2] Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 95064 USA

[3] Nova SE Univ, Oceanog Ctr, Ft Lauderdale, FL 33004 USA

来源：

ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 3 | 2015年 / 3卷

基金：

美国国家科学基金会;

关键词：

mammal; amphibian; reptile; bird; fish; genome; GENERATION SEQUENCING DATA; COPY NUMBER VARIATION; DE-NOVO DETECTION; PROVIDES INSIGHTS; DRAFT GENOME; REVEALS INSIGHTS; EVOLUTIONARY ADAPTATION; COMPETITIVE ASSESSMENT; CONVERGENT EVOLUTION; CHROMOSOME EVOLUTION;

D O I：

10.1146/annurev-animal-090414-014900

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The Genome 10K Project was established in 2009 by a consortium of biologists and genome scientists determined to facilitate the sequencing and analysis of the complete genomes of 10,000 vertebrate species. Since then the number of selected and initiated species has risen from similar to 26 to 277 sequenced or ongoing with funding, an approximately tenfold increase in five years. Here we summarize the advances and commitments that have occurred by mid-2014 and outline the achievements and present challenges of reaching the 10,000-species goal. We summarize the status of known vertebrate genome projects, recommend standards for pronouncing a genome as sequenced or completed, and provide our present and future vision of the landscape of Genome 10K. The endeavor is ambitious, bold, expensive, and uncertain, but together the Genome 10K Consortium of Scientists and the worldwide genomics community are moving toward their goal of delivering to the coming generation the gift of genome empowerment for many vertebrate species.

引用

页码：57 / 111

页数：55

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