Examining the relationships between adverse childhood experiences (ACEs), cortisol, and inflammation among young adults

被引：11

作者：

Wong, Kingston E. ^{[1
]}

Wade, Terrance J. ^{[1
,2
,3
,5
]}

Moore, Jessy ^{[1
]}

Marcellus, Ashley ^{[4
]}

Molnar, Danielle S. ^{[2
]}

O'Leary, Deborah D. ^{[1
,3
]}

Macneil, Adam J. ^{[1
]}

机构：

[1] Brock Univ, Dept Hlth Sci, St Catharines, ON, Canada

[2] Brock Univ, Dept Child & Youth Studies, St Catharines, ON, Canada

[3] Brock Niagara Ctr Hlth & Well Being, Thorold, ON, Canada

[4] Nipissing Univ, Dept Psychol, North Bay, ON, Canada

[5] Brock Univ, Fac Appl Hlth Sci, Dept Hlth Sci, 1812 Sir Isaac Brock Way, St Catharines, ON L2S 3A1, Canada

来源：

BRAIN BEHAVIOR & IMMUNITY-HEALTH | 2022年 / 25卷

基金：

加拿大健康研究院;

关键词：

Adverse childhood experiences; ACEs; Cortisol; Inflammation; Biomarkers; HAIR CORTISOL; SIGNAL-TRANSDUCTION; STRESS; DISORDER; BIOMARKER; VICTIMS; ABUSE; ALPHA; GAMMA;

D O I：

10.1016/j.bbih.2022.100516

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adverse childhood experiences (ACEs) are associated with dysregulation of inflammation and cortisol. The objectives of this study were to use principal component analysis to explore the inflammatory biomarker data to create inflammation composite variables; to examine the relationship between these composite measures of inflammation with ACEs and cortisol; and to assess whether these relationships were moderated by sex. The analysis included 232 young adults from the Niagara Longitudinal Heart Study (NLHS). After adjusting for covariates, higher exposure to ACEs significantly predicted higher low-grade inflammation. These results further support the use of multiple biomarkers to understand the complex relationships among ACEs, cortisol, and inflammation, which should be further examined in longitudinal studies to study biomarker trajectories.

引用

页数：12

共 54 条

[1]

Aas M., 2017, Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses, P8

[2] How corticosteroids control inflammation: Quintiles prize lecture 2005 [J].

Barnes, Peter J. .

BRITISH JOURNAL OF PHARMACOLOGY, 2006, 148 (03) :245-254

[3] Inflammation and Early-Life Abuse in Women [J].

Bertone-Johnson, Elizabeth R. ;

Whitcomb, Brian W. ;

Missmer, Stacey A. ;

Karlson, Elizabeth W. ;

Rich-Edwards, Janet W. .

AMERICAN JOURNAL OF PREVENTIVE MEDICINE, 2012, 43 (06) :611-620

[4] Childhood Trauma, Perceived Stress, and Hair Cortisol in Adults With and Without Cardiovascular Disease [J].

Bosse, Stephanie ;

Stalder, Tobias ;

D'Antono, Bianca .

PSYCHOSOMATIC MEDICINE, 2018, 80 (04) :393-402

[5] Signal transduction by tumor necrosis factor receptors [J].

Cabal-Hierro, Lucia ;

Lazo, Pedro S. .

CELLULAR SIGNALLING, 2012, 24 (06) :1297-1305

[6]

Childhood Trust, 2017, Cincinnati Children's Hospital Medical Center. Childhood Trust Events Survey 2.0-Caregiver and Child Version

[7] Diverse patterns of neuroendocrine activity in maltreated children [J].

Cicchetti, D ;

Rogosch, FA .

DEVELOPMENT AND PSYCHOPATHOLOGY, 2001, 13 (03) :677-693

[8] Childhood maltreatment and inflammatory markers: a systematic review [J].

Coelho, R. ;

Viola, T. W. ;

Walss-Bass, C. ;

Brietzke, E. ;

Grassi-Oliveira, R. .

ACTA PSYCHIATRICA SCANDINAVICA, 2014, 129 (03) :180-192

[9]

Cohen J., 2003, Applied multiple regression/ correlation analysis for the behavioral sciences, V3rd, DOI [10.4324/9780203774441, DOI 10.4324/9780203774441]

[10] Soluble TNF and IL-6 receptors: Indicators of vascular health in women without cardiovascular disease [J].

Cortez-Cooper, Miriam ;

Meaders, Eric ;

Stallings, Judith ;

Haddow, Sara ;

Kraj, Barbara ;

Sloan, Gloria ;

McCully, Kevin K. ;

Cannon, Joseph G. .

VASCULAR MEDICINE, 2013, 18 (05) :282-289

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