CNS response after erlotinib therapy in a patient with metastatic NSCLC with an EGFR mutation

被引：14

作者：

Pan, Minggui

Santamaria, Monica

Wollman, David B.

机构：

[1] Kaiser Permanente Med Ctr, Div Hematol & Oncol, Santa Clara, CA 95051 USA

[2] Kaiser Permanente Med Ctr, Dept Pathol, Santa Clara, CA 95051 USA

[3] Kaiser Permanente Med Ctr, Dept Radiol, Santa Clara, CA 95051 USA

来源：

NATURE CLINICAL PRACTICE ONCOLOGY | 2007年 / 4卷 / 10期

关键词：

CNS metastasis; EGFR; erlotinib; gefitinib; non-small-cell lung cancer;

D O I：

10.1038/ncponc0931

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background A 73-year-old Asian man with a history of lipidemia, hypertension and myocardial infarction presented with dizziness, decreased appetite, weight loss, nonproductive cough and fatigue. His physical performance status was good, and physical examination was unremarkable except for lower-extremity pitting edema. Investigations Physical examination, brain MRI, CT scans of the chest, abdomen and pelvis, bone scan, CT scan-guided biopsy, hematoxylin and eosin staining, EGFR mutational analysis, and chest X-ray. Diagnosis Stage IV non-small-cell lung cancer with brain metastasis. Management Oral erlotinib 150 mg daily for 10 months and ongoing, and whole-brain irradiation.

引用

页码：603 / 607

页数：5

共 19 条

[11] EGFR mutations in lung cancer:: Correlation with clinical response to gefitinib therapy [J].

Paez, JG ;

Jänne, PA ;

Lee, JC ;

Tracy, S ;

Greulich, H ;

Gabriel, S ;

Herman, P ;

Kaye, FJ ;

Lindeman, N ;

Boggon, TJ ;

Naoki, K ;

Sasaki, H ;

Fujii, Y ;

Eck, MJ ;

Sellers, WR ;

Johnson, BE ;

Meyerson, M .

SCIENCE, 2004, 304 (5676) :1497-1500

[12] Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain [J].

Pao, W ;

Miller, VA ;

Politi, KA ;

Riely, GJ ;

Somwar, R ;

Zakowski, MF ;

Kris, MG ;

Varmus, H .

PLOS MEDICINE, 2005, 2 (03) :225-235

[13] EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib [J].

Pao, W ;

Miller, V ;

Zakowski, M ;

Doherty, J ;

Politi, K ;

Sarkaria, I ;

Singh, B ;

Heelan, R ;

Rusch, V ;

Fulton, L ;

Mardis, E ;

Kupfer, D ;

Wilson, R ;

Kris, M ;

Varmus, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (36) :13306-13311

[14] Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: Current knowledge and future directions [J].

Pao, W ;

Miller, VA .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (11) :2556-2568

[15] Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer [J].

Sandler, Alan ;

Gray, Robert ;

Perry, Michael C. ;

Brahmer, Julie ;

Schiller, Joan H. ;

Dowlati, Afshin ;

Lilenbaum, Rogerio ;

Johnson, David H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (24) :2542-2550

[16] Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer [J].

Schiller, JH ;

Harrington, D ;

Belani, CP ;

Langer, C ;

Sandler, A ;

Krook, J ;

Zhu, JM ;

Johnson, DH .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (02) :92-98

[17] Erlotinib in previously treated non-small-cell lung cancer [J].

Shepherd, FA ;

Pereira, JR ;

Ciuleanu, T ;

Tan, EH ;

Hirsh, V ;

Thongprasert, S ;

Campos, D ;

Maoleekoonpiroj, S ;

Smylie, M ;

Martins, R ;

van Kooten, M ;

Dediu, M ;

Findlay, B ;

Tu, DS ;

Johnston, D ;

Bezjak, A ;

Clark, G ;

Santabárbara, P ;

Seymour, L .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (02) :123-132

[18] EGFR mutations in patients with brain metastases from lung cancer:: Association with the efficacy of gefitinib [J].

Shimato, S ;

Mitsudomi, T ;

Kosaka, T ;

Yatabe, Y ;

Wakabayashi, T ;

Mizuno, M ;

Nakahara, N ;

Hatano, H ;

Natsume, A ;

Ishii, D ;

Yoshida, J .

NEURO-ONCOLOGY, 2006, 8 (02) :137-144

[19] Erlotinib in lung cancer - Molecular and clinical predictors of outcome [J].

Tsao, MS ;

Sakurada, A ;

Cutz, JC ;

Zhu, CQ ;

Kamel-Reid, S ;

Squire, J ;

Lorimer, I ;

Zhang, T ;

Liu, N ;

Daneshmand, M ;

Marrano, P ;

Santos, GD ;

Lagarde, A ;

Richardson, F ;

Seymour, L ;

Whitehead, M ;

Ding, KY ;

Pater, J ;

Shepherd, FA .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (02) :133-144

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