Interplay between oxidant species and energy metabolism

被引:235
作者
Quijano, Celia [1 ]
Trujillo, Madia
Castro, Laura
Trostchansky, Andres [1 ]
机构
[1] Univ Republica, Dept Bioquim, Fac Med, Ave Gen Flores 2125, Montevideo 11800, Uruguay
关键词
Reactive oxygen species; Energy metabolism; Mitochondria; Reactive nitrogen species; ALPHA-KETOGLUTARATE DEHYDROGENASE; MANGANESE SUPEROXIDE-DISMUTASE; HYDROGEN-PEROXIDE GENERATION; ACYL-COA OXIDASE; MITOCHONDRIAL ELECTRON-TRANSPORT; PENTOSE-PHOSPHATE PATHWAY; NITRIC-OXIDE; OXIDATIVE STRESS; CYTOCHROME-C; XANTHINE-OXIDASE;
D O I
10.1016/j.redox.2015.11.010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It has long been recognized that energy metabolism is linked to the production of reactive oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by redox reactions. This interplay between energy metabolism and ROS becomes most apparent during the aging process and in the onset and progression of many age-related diseases (i.e. diabetes, metabolic syndrome, atherosclerosis, neurodegenerative diseases). As such, the capacity to identify metabolic pathways involved in ROS formation, as well as specific targets and oxidative modifications is crucial to our understanding of the molecular basis of age-related diseases and for the design of novel therapeutic strategies. Herein we review oxidant formation associated with the cell's energetic metabolism, key antioxidants involved in ROS detoxification, and the principal targets of oxidant species in metabolic routes and discuss their relevance in cell signaling and age-related diseases. (C) 2015 The Authors. Published by Elsevier B.V.
引用
收藏
页码:28 / 42
页数:15
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