Quality control techniques for routine analysis with liquid chromatography in laboratories

The process of quality assurance should demonstrate that the method and the analytical instrument provide accurate and precise results, or whether deterioration occurs. For this, the quality procedure should include tests which provide information on the characteristic performance of the method. According to the recent literature, useful procedures contributing to the overall quality of analytical results are illustrated in relation with liquid chromatography. Parameters examined are carry-over, column statement, accuracy and precision. The performance of the whole system from the extraction to measurement of analytes of interest must be monitored with control charts. Data representing the routine performance of chromatographic equipment systems and method allow predicting long-term uncertainties and confidence intervals. (c) 2007 Elsevier B.V. All rights reserved.