Design of Metal-Organic Frameworks for pH-Responsive Drug Delivery Application

被引：17

作者：

Shen, Xin ^{[1
]}

Pan, Ying ^{[1
]}

Sun, Zhihao ^{[2
]}

Liu, Dong ^{[3
]}

Xu, Hongjia ^{[1
]}

Yu, Qian ^{[1
]}

Trivedi, Manoj ^{[4
]}

Kumar, Abhinav ^{[5
]}

Chen, Jinxiang ^{[6
]}

Liu, Jianqiang ^{[1
]}

机构：

[1] Guangdong Med Univ, Sch Pharm, Dongguan Key Lab Drug Design & Formulat Technol, Key Lab Res & Dev New Med Mat, Dongguan 523808, Peoples R China

[2] Dongguan City Maternal & Child Hlth Hosp, Dongguan 523000, Peoples R China

[3] Shenzhen Huachuang Biopharmaceut Technol Co Ltd, Shenzhen 518112, Guangdong, Peoples R China

[4] Univ Delhi, Dept Chem, Delhi, India

[5] Univ Lucknow, Fac Sci, Dept Chem, Lucknow 226007, Uttar Pradesh, India

[6] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2019年 / 19卷 / 20期

关键词：

Drug delivery; biomedical imaging; photodynamic therapy; Metal-Organic Frameworks (MOFs); Porous Coordination Polymers (PCPs); Photodynamic Therapy (PDT); EFFECTIVE PHOTODYNAMIC THERAPY; COORDINATION POLYMERS; MAGNETIC-RESONANCE; CONTRAST AGENTS; CONTROLLABLE SYNTHESIS; CONTROLLED-RELEASE; MESOPOROUS SILICA; IN-VITRO; NANOPARTICLES; CANCER;

D O I：

10.2174/1389557519666190722164247

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Metal-Organic Frameworks (MOFs) have aroused great interest in the field of nanoscience and nanotechnology particularly in biomedical domains, such as Drug Delivery System (DDS), Biomedical Imaging (BI) and Photodynamic Therapy (PDT). As an emerging material, MOFs possess extraordinarily high surface area, controllable particle size and good biocompatibility. With extraordinary flexibility in the selection of organic and inorganic components, MOFs can rationally be tuned to obtain the materials having versatile structures and porosities. MOFs can serve as ideal vehicles for DDS, BI and PDT through modification and function. In this review, we summarized the design and synthetic strategies for preparing MOFs and introduced their recent advanced usage in DDS, BI and PDT. Finally, the prospect and future challenges of these nanomaterials are also documented.

引用

页码：1644 / 1665

页数：22

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