A C-H Activation Approach to the Tricyclic Core of Glionitrin A and B

被引：0

作者：

Koning, Nicolas R. ^{[1
]}

Strand, Daniel ^{[1
]}

机构：

[1] Lund Univ, Dept Chem, Ctr Anal & Synth, SE-22100 Lund, Sweden

来源：

ACS OMEGA | 2022年 / 7卷 / 14期

基金：

瑞典研究理事会;

关键词：

CONCISE TOTAL-SYNTHESIS; GLIOTOXIN; DIPEPTIDES; ANALOGS; DIKETOPIPERAZINES; DEHYDROGLIOTOXIN; METABOLITE; ALKALOIDS; DISCOVERY; OXIDATION;

D O I：

10.1021/acsomega.2c00810

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of diketopiperazines has been of long-standing interest in both natural product synthesis and medicinal chemistry. Here, we present an operationally convenient and efficient approach to the fused indoline-diketopiperazine tricyclic core of glionitrin A/B and related structures using a Pd-catalyzed C-H activation reaction to form the indoline five-membered ring. Exploratory work aimed at elaborating the tricyclic structures into the corresponding natural products is discussed.

引用

页码：12329 / 12341

页数：13

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