Comparison of the activity of ACTH 4-10 fragment and analogue and tripeptide Pro-Gly-Pro during 3-hour-observation of rabbits' behaviour under acute stress conditions

A comparative analysis was made on the influence of corticotropin oligopeptides on rabbits' behaviour under acute stress conditions, or after the electrostimulation of the Vmh. The 4-10 fragment and analogue of corticotropin and tripeptide Pro-Gly-Pro was administered icv to the rabbits. It was proved that the analogue and 4-10 fragment had a significant influence on modification of animals' behaviour under acute stress conditions. There were, however, considerable differences between them in the form of reduction of the dynamics and time of reaction of analogue 4-10, which were the effect of the change of amino-acid-sequence. The applied tripeptide Pro-Gly-Pro had a marginal role in the change of rabbits' behavioural pattern. The oligopeptides: 4-10 fragment and analogue of corticotropin significantly increased the positive behaviours that limited the extent and scale of stress influence on the organism.